Korean J Dermatol.  1994 Apr;32(2):321-326.

A Case of Type III Hyperlipoproteinemia Associate with Xanthoma Tuberosum and Xanthoma Striatum Palmare

• Cho NJ
• Lew W
• Kim JH
• Lee SH

Abstract

We report a case of type III hyperlipoproteinemia associated with xanthoma eruptivum. Xanthoma tuberosum, and xanthoma striatum palmare whose clinical symptoms have been improved by the treatment of gemfibrozil. A 31-year-old male patient visited our clinic for evaluation of multiple yellowish nodules on the elbows, multiple yellowish plaques on the buttocks and linear yellowish plaques along with the palmar creases on both palms. The blood chemistry showed an elevation of cholesterol and triglyceride. Lipoprotein electrophoresis showed broad betazone and plasma standing test showed turbid plasma. Lipoprotein ultracentrifugation showed that the ratio of VLDL cholesterol and plasma triglyceride was 0.38. According to the above findings, we diagnosed this patient as type III hyperlipoproteinemia. After 4 months of treatment with diet and gemfibrozil, the serum level of cholesterol and triglyceride were reduced to normal range. The skin lesions of both palms showed marked improvement but the skin lesions on elbows and buttocks were not much improved.

MeSH Terms

Adult
Buttocks
Chemistry
Cholesterol
Cholesterol, VLDL
Diet
Elbow
Electrophoresis
Gemfibrozil
Humans
Hyperlipoproteinemia Type III*
Lipoproteins
Male
Plasma
Reference Values
Skin
Triglycerides
Ultracentrifugation
Xanthomatosis*
Cholesterol
Cholesterol, VLDL
Gemfibrozil
Lipoproteins