Korean Circ J.  1990 Dec;20(4):815-818. 10.4070/kcj.1990.20.4.815.

Clinical Effects of Isosorbide 5-Mononitrate(Elantan(R)) on Angina Pectoris

• Lee JY
• Lee DI
• Shin JA
• Cha KS
• Lee MK
• Hu JY
• Shin YW
• Shin YK

• KMID: 2229362
• DOI: http://doi.org/10.4070/kcj.1990.20.4.815

Abstract

An open trial was carried out to investigate the efficacy and tolerance of isosorbide 5-mononitrate(Elantan(R)) in 30 patients diagnosed as angina pectoris at Pusan national university hospital. Drugs were given 20mg two times daily for 2 to 3 weeks and the results were assessed in terms of effects on anginal pain and untoward side effects experienced during administration of medication. Treament resulted in an overall improvement in 25 patients(83.4%), complete abolition of anginal attacks in 17 patients(56.7%) and reduction in frequency of attacks in 8 patients(26.7%). So called "Nitrated headache" was observed in 5 patients(16.6%) but improved with proceeding of administration in 3 patients. This trial indicates that isosorbide 5-mononitrate should be efficacious as well as tolerated in patients with coronary heart disease.

Keyword

Isosorbide 5-mononitrate; Angina pectoris

MeSH Terms

Angina Pectoris*
Busan
Coronary Disease
Humans
Isosorbide*
Isosorbide