Korean J Crit Care Med.  2010 Dec;25(4):271-275. 10.4266/kjccm.2010.25.4.271.

Diffuse Alveolar Hemorrhage Subsequently Developed after Recovery from Severe Acute Lung Injury Caused by H1N1 Influenza Infection: A Case Report

Affiliations
  • 1Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea. jclee@kcch.re.kr
  • 2Department of Radiology, Korea Cancer Center Hospital, Seoul, Korea.
  • 3Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea.
  • 4Department of Internal Medicine, Bohun Hospital, Seoul, Korea.

Abstract

Severe acute lung injury (ALI), leading to respiratory failure caused by H1N1 infection, developed in a 34-year-old man during a work-up for non-small cell lung cancer. Although he fully recovered through instant treatment with oseltamivir, mechanical ventilation was required again, 7 days later, due to subsequent diffuse alveolar hemorrhage (DAH). Finally, his condition improved and he was able to move out of the intensive care unit. However, multiple pulmonary metastatic nodules appeared over a period of one month, suggesting the aggressive nature of lung cancer. Although he was discharged after chemotherapy, his prognosis seemed poor, considering the rapidity of growth of the lung cancer. It is important to recognize that DAH can occur after acute lung injury caused by influenza virus.

Keyword

acute lung injury; diffuse alveolar hemorrhage; influenza A virus H1N1 subtype

MeSH Terms

Acute Lung Injury
Adult
Carcinoma, Non-Small-Cell Lung
Hemorrhage
Humans
Influenza, Human
Intensive Care Units
Lung Neoplasms
Orthomyxoviridae
Oseltamivir
Prognosis
Respiration, Artificial
Respiratory Insufficiency
Oseltamivir
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