Korean Circ J.  2004 Oct;34(10):937-944. 10.4070/kcj.2004.34.10.937.

Long-Term Effect of Repeated Brachytherapy in Intracoronary Brachytherapy Failed Lesions

• Bae JW
• Kang HJ
• Kim KI
• Cho YS
• Youn TJ
• Koo BK
• Chae IH
• Lee MM
• Oh BH
• Park YB
• Choi YS

• KMID: 2227188
• DOI: http://doi.org/10.4070/kcj.2004.34.10.937

Abstract

BACKGROUND AND OBJECTIVES
An intracoronary brachytherapy is the only approved treatment for in-stent restenosis. However, a considerable rate of restenosis occurs after a brachytherapy. Up to now, there was no long term outcome for repeated brachytherapy for these lesions.
SUBJECTS AND METHODS
Eleven patients were admitted due to angina, with significant ischemic evidence in the stress test after the intracoronary brachytherapy. These patients were re-treated with a beta-emitting 188 rhenium-DTPA (diethylene triamine penta-acetic acid) filled balloon catheter system, using an identical method and radiation dose (17.6 Gy) to the initial radiation treatment. The long term angiographic and clinical outcomes of repeated brachytherapy in these patients were evaluated.
RESULTS
The angiographic and clinical data of ten patients were evaluated, as 1 was lost. The follow-up period was 37.4+/-16.2 months (range, 8 to 53 months). There was no angiographic restenosis or target lesion revascularization (TLR) during the short term follow-up period (mean 6 months). but 2 restenosis (25%) occurred in the 2 year follow-up period and one other was added during the long term clinical follow-up period. All these restenosis lesions needed revascularization. These three TLRs occurred at 15, 24 and 43 months after the repeated brachytherapy. There was no death or nonfatal MI. No vascular perforation, aneurysm or late thrombosis was observed.
CONCLUSION
A repeated brachytherapy for the treatment of a failed intracoronary brachytherapy lesion is safe and acceptably effective during the long term follow-up period. This modality might be considered as a therapeutic option for failed intracoronary brachytherapy lesions.

Keyword

Coronary disease; Brachytherapy; Restenosis

MeSH Terms

Aneurysm
Brachytherapy*
Catheters
Coronary Disease
Exercise Test
Follow-Up Studies
Humans
Thrombosis