Korean Circ J.  2005 Dec;35(12):910-915. 10.4070/kcj.2005.35.12.910.

Comparison of Endothelium-Dependent Vasodilation According to the Presence of Diabetes in Coronary Artery Disease

Affiliations
  • 1Department of Internal Medicine, Hanyang University College of Medicin, Seoul, Korea. limhg@hanyang.ac.kr

Abstract

BACKGROUND AND OBJECTIVES
The purpose of this study is to evaluate endothelium dependent vasodilation in the diabetic patients suffering with coronary artery disease (CAD).
SUBJECTS AND METHODS
43 patients who presented with typical chest pain and who underwent coronary angiography were enrolled in this study. They were classified into diabetic patients with CAD (n=13), non-diabetic patients with CAD (n=13), diabetic patients without CAD (n=7), and non-diabetic patients without CAD (n=10), according to the presence of CAD and diabetes mellitus. Endothelium-dependent vasodilation of the brachial artery was measured in all the subjects by performing 7.5 MHz high-resolution ultrasound sonography.
RESULTS
The endothelium-dependent vasodilation in the diabetic patients with CAD was 1.30+/-2.13% and it was 5.72+/-3.70% in the non-diabetic patients with CAD. There was a significant difference between the two groups (p=0.001). The endothelium-dependent vasodilation in diabetic patients without CAD was 2.28+/-1.88% and it was 10.70+/-10.19% in the non-diabetic patients without CAD. There was a significant difference between the two groups (p=0.029). The endothelium-dependent vasodilations in the diabetic group was 2.28+/-1.88% and it was 10.70+/-10.19% in the non-diabetic group for all the patients. There was a significant difference between the two groups (p=0.029). There was correlation between the endothelium-dependent vasodilation and the fasting blood sugar. There was negative correlation between the endothelium-dependent vasodilation and the fasting blood sugar (FBS) in the patients with CAD (r=-0.59, p=0.002). However, there was no correlation between the endothelium-dependent vasodilation and the FBS in the patients without CAD (r=-0.327, p=0.201). There was negative correlation between the endothelium-dependent vasodilation and the FBS in all subjects (r=-0.352, p=0.021).
CONCLUSION
The endothelium-dependent vasodilation was decreased in the diabetic patients with CAD as compared to the non-diabetic patients with CAD. There was also was negative correlation between the endothelium-dependent vasodilation and the FBS in the patients with CAD.

Keyword

Coronary artery disease; Diabetes mellitus; Endothelium-dependent vasodilation

MeSH Terms

Blood Glucose
Brachial Artery
Chest Pain
Coronary Angiography
Coronary Artery Disease*
Coronary Vessels*
Diabetes Mellitus
Endothelium
Fasting
Humans
Ultrasonography
Vasodilation*
Blood Glucose
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