Korean Circ J.  2012 Aug;42(8):562-564. 10.4070/kcj.2012.42.8.562.

A Case of Severe Pulmonary Thromboembolism in a Young Male With Klinefelter Syndrome

• Kang BS
• Cho DK
• Koh WJ
• Yoo SH
• Won KB
• Cho YH
• Hwang ES
• Koh JH

• KMID: 2225007
• DOI: http://doi.org/10.4070/kcj.2012.42.8.562

Abstract

A young male patient diagnosed with Klinefelter syndrome was admitted to our hospital via the emergency room with chief complaints of acute chest pain and dyspnea. Pulmonary thromboembolism was diagnosed from his chest CT images. His symptoms improved after he underwent thrombolysis and anticoagulation treatment. Klinefelter syndrome has a tendency towards hypercoagulability due to hormonal imbalance and one or more inherited thromophilic factors. Thus, Klinefelter syndrome patients with a past medical history of venous thromboembolism require continuous oral anticoagulation therapy for a period of at least six months.

Keyword

Klinefelter syndrome; Pulmonary embolism; Venous thrombosis

MeSH Terms

Chest Pain
Dyspnea
Emergencies
Humans
Klinefelter Syndrome
Male
Pulmonary Embolism
Thorax
Thrombophilia
Venous Thromboembolism
Venous Thrombosis

Figure

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  Fig. 1 Chromosomal analysis revealed a karyotype of 47, XXY, which is a typical finding for Klinefelter syndrome.

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  Fig. 2 Contrast enhanced chest computed tomography on admission. Multiple thromboembolism (white arrows) in main, lobar, segmental and subsegmental pulmonary arteries of both lungs.

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  Fig. 3 In the lower extremity vascular computed tomography, deep vein thrombosis was observed in the distal portion of the left popliteal vein (white arrows).

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