Korean Circ J.  2013 Dec;43(12):819-824. 10.4070/kcj.2013.43.12.819.

Do Different Arterial Stiffness Parameters Provide Similar Information in High-Risk Patients for Coronary Artery Disease?

• Kim KM
• Yoo BS
• Ko A
• Kim JM
• Kim HS
• Lee JW
• Kim JY
• Youn YJ
• Ahn SG
• Lee SH
• Yoon J

• KMID: 2224776
• DOI: http://doi.org/10.4070/kcj.2013.43.12.819

Abstract

BACKGROUND AND OBJECTIVES
The aim of our study was to compare the values of brachial-ankle pulse wave velocity (baPWV) measured with two different non-invasive methods as predictors of coronary artery disease (CAD) in patients who had undergone coronary angiography.
SUBJECTS AND METHODS
From 6373 patients who visited our laboratory for non-invasive procedures, we enrolled 965 consecutive patients undergoing coronary angiography. Data for baPWV and peripheral augmentation index (pAI) were recorded. CAD was defined as greater than 50% stenosis of a major epicardial artery in a coronary angiogram. In addition, the severity of CAD was classified as: none/minimal or 1-, 2-, or 3-vessel disease, based on previous or current angiographic findings.
RESULTS
Among 965 subjects, the mean age was 63.7+/-11.6 years, and 58.2% were male. Compared with subjects without CAD disease, those with CAD showed higher values of baPWV (16.6+/-3.5 m/sec vs. 15.9+/-3.4 m/sec, p<0.001), and lower values of pAI (73.5+/-15.9% vs. 76.0+/-15.7%, p=0.01). When the severity of CAD was expressed as none/minimal or 1-, 2-, or 3-vessel disease, there was a significant association between the extent of CAD and baPWV (p<0.001). In univariate analysis, high PWV and low pAI were associated with an increased prevalence of CAD (p<0.001).
CONCLUSION
Increased baPWV and decreased pAI were associated with the presence of CAD in the elderly.

Keyword

Pulse wave velocity; Coronary artery disease; Arterial stiffness

MeSH Terms

Aged
Arteries
Constriction, Pathologic
Coronary Angiography
Coronary Artery Disease*
Coronary Vessels*
Humans
Male
Prevalence
Pulse Wave Analysis
Vascular Stiffness*

Figure

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  Fig. 1 Study flow chart. ABI: ankle brachial index.

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