Korean J Clin Microbiol.  2005 Apr;8(1):47-50.

The Prevalence of Antimicrobial Resistance in Helicobacter pylori Isolated in Daejeon

Affiliations
  • 1Department of Laboratory medicine, Keonyang University Hospital, Daejeon, Korea. lee4@kyuh.co.kr
  • 2Department of Internal Medicine, Keonyang University Hospital, Daejeon, Korea.
  • 3Department of Pathology, Keonyang University Hospital, Daejeon, Korea.
  • 4Department of Internal Medicine, Inha University Hospital, Incheon, Korea.
  • 5Department of Food and Nutrition, Seoil College, Seoul, Korea.

Abstract

BACKGROUND
The most commonly used regimen for the eradication of Helicobacter pylori is combination of a proton pump inhibitor, clarithromycin, and two other antibiotics, metronidazole and amoxicillin. The increase in resistance to antibiotics seems to result in a decrease in eradication efficacy for H.pylori. We investigated the prevalence of antibiotic resistance in H.pylori isolated in Daejeon area.
METHODS
A total of 31 clinical isolates of H.pylori were collected from the patients who underwent upper gastrointestinal endoscopy in Keonyang University Hospital during the period from March to July 2004. Antibiotic susceptibility tests for metronidazole, amoxicillin, and clarithromycin were performed by the E test (AB Biodisk, Sweden) on an egg yolk medium containing triphenyltetrazolium. The resistance break points for amoxicillin, metronidazole, and clarithromycin were defined as 0.5 microgram/mL, 8 microgram/mL, 1 microgram/mL, respectively.
RESULTS
Resistance to amoxicillin, metronidazole, and clarithromycin was detected in 7.4% (2/27), 25.8% (8/31), 3.6% (1/28), respectively.
CONCLUSION
The resistance to amoxicillin and clarithromycin was uncommon in Daejeon area.

Keyword

Helicobacter pylori; Antimicrobial resistance; Amoxicillin; Metronidazole; Clarithromycin

MeSH Terms

Amoxicillin
Anti-Bacterial Agents
Clarithromycin
Drug Resistance, Microbial
Egg Yolk
Endoscopy, Gastrointestinal
Helicobacter pylori*
Helicobacter*
Humans
Metronidazole
Prevalence*
Proton Pumps
Amoxicillin
Anti-Bacterial Agents
Clarithromycin
Metronidazole
Proton Pumps
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