Kidney Res Clin Pract.  2012 Mar;31(1):54-61.

The effect of depression and health-related quality of life on the outcome of hemodialysis patients

• Jeon HJ
• Park HC
• Park JI
• Lee JP
• Oh KH
• Chin HJ
• Joo KW
• Kim YS
• Lim CS
• Ahn C
• Han JS
• Kim S
• Oh YK

Abstract

BACKGROUND
In hemodialysis (HD) patients, traditional risk factors cannot explain all of the mortality and morbidity. This study was designed to investigate the effect of depression and health-related quality of life (HRQOL) on prognosis in maintenance HD patients.
METHODS
In February 2008, the Beck's Depression Inventory and the Kidney Dialysis Quality of Life-Short Form were utilized to measure depression and HRQOL. Until February 2011, the mortality, cardiovascular events, infection, and hospitalization were investigated, retrospectively.
RESULTS
Among the 166 patients, the 3-year cumulative survival rate was 88.8%, and the depression did not affect survival (depression vs. nondepression: 91.8% vs. 87.2%, P=0.437). The upper tertiles in physical component summary (PCS) were correlated with lower mortality (OR, 0.12; P=0.05) and fewer cardiovascular events (OR, 0.09; P=0.024) than the lower tertiles. The upper tertiles in kidney disease component summary (KDCS) were associated with less hospitalization than the lower tertiles (OR, 0.38; P=0.024). After adjusting for multiple variables including age, comorbidity index, and albumin, upper tertiles in PCS were correlated with fewer cardiovascular events than the lower tertiles (OR, 0.08; P=0.038).
CONCLUSION
The cross-sectional survey of whether HD patients had depression was not significantly associated with mortality and morbidity. HRQOL was correlated with mortality, cardiovascular events and hospitalization.

Keyword

Depression; Hemodialysis; Outcome; Quality of life

MeSH Terms

Comorbidity
Cross-Sectional Studies
Depression
Dialysis
Hospitalization
Humans
Kidney
Kidney Diseases
Prognosis
Quality of Life
Renal Dialysis
Risk Factors
Survival Rate