Kidney Res Clin Pract.  2014 Dec;33(4):187-191. 10.1016/j.krcp.2014.07.006.

Reanalysis of membranoproliferative glomerulonephritis patients according to the new classification: a multicenter study

• Woo SA
• Ju HY
• Kwon SH
• Lee JH
• Choi SJ
• Han DC
• Hwang SD
• Hong SY
• Jin SY
• Gil HW

• KMID: 2224259
• DOI: http://doi.org/10.1016/j.krcp.2014.07.006

Abstract

BACKGROUND
All types of membranoproliferative glomerulonephritis (MPGN) are progressive diseases with poor prognoses. Recently, a newly proposed classification of these diseases separated them into immune complex- and complement- mediated diseases. We investigated the frequency of C3 glomerulonephritis among previously diagnosed MPGN patients.
METHODS
We conducted a retrospective study of patients diagnosed with MPGN at three tertiary care institutions between 2001 and 2010. We investigated the incidence of complement-mediated disease among patients diagnosed with MPGN. Progressive renal dysfunction was defined as a 50% reduction in the glomerular filtration rate or the need for renal replacement therapy.
RESULTS
Among the 3,294 renal biopsy patients, 77 (2.3%) were diagnosed with MPGN; 31 cases were excluded, of which seven were diagnosed with systemic lupus nephritis, and the others were not followed for a minimum of 12 months after biopsy. Based on the new classification, complement-mediated MPGN was diagnosed in two patients (4.3%); only one patient developed progressive renal dysfunction. Among the immune complex-mediated MPGN patients, 17 patients developed progressive renal dysfunction. Serum albumin and creatinine levels at the time of MPGN diagnosis were risk factors of renal deterioration, after adjusting for low C3 levels and nephrotic syndrome.
CONCLUSION
Complement-mediated glomerulonephritis was present in 4.3% of patients previously diagnosed with MPGN.

Keyword

Complement C3; Membranous glomerulonephritis; Incidence

MeSH Terms

Biopsy
Classification*
Complement C3
Creatinine
Diagnosis
Glomerular Filtration Rate
Glomerulonephritis
Glomerulonephritis, Membranoproliferative*
Glomerulonephritis, Membranous
Humans
Incidence
Lupus Nephritis
Nephrotic Syndrome
Prognosis
Renal Replacement Therapy
Retrospective Studies
Risk Factors
Serum Albumin
Tertiary Healthcare
Complement C3
Creatinine
Serum Albumin