Korean Circ J.  2014 Nov;44(6):400-405. 10.4070/kcj.2014.44.6.400.

Slow Coronary Flow Phenomenon and Increased Platelet Volume Indices

• Seyyed-Mohammadzad MH
• Khademvatani K
• Kerachian
• Eskandari
• Rezaei Y

• KMID: 2223856
• DOI: http://doi.org/10.4070/kcj.2014.44.6.400

Abstract

BACKGROUND AND OBJECTIVES
We sought to determine the relationship between mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) with slow coronary flow (SCF).
SUBJECTS AND METHODS
Eighty participants who underwent coronary angiography were divided into two groups, 50 participants with SCF as case group, and 30 with normal coronary flow (NCF) as control group. Baseline characteristics and laboratory data were collected before angiography.
RESULTS
Platelet volume indices MPV (10.8+/-1.2 fL), PDW (14.5+/-2.2 fL), and P-LCR (30.5+/-8.1%) in the SCF group were significantly (p<0.05) higher than those (10.1+/-0.9 fL, 13.2+/-1.8 fL, and 26.8+/-6.8%, respectively) in the NCF group. The patients with three SCF arteries had significantly higher platelet volume indices compared to those with NCF arteries; however, the patients with one SCF artery did not. Based on linear regression model, MPV, PDW, and P-LCR were independent predictors of mean infarction frame counting (TFC). In multivariate analysis, MPV {odds ratio (OR)=32.393, 95% confidence interval (CI)=1.189-882.606, p=0.039} and P-LCR (OR=0.566, 95% CI=0.330-0.937, p=0.028) were independent predictors of SCF.
CONCLUSION
Platelet volume indices MPV, PDW, and P-LCR were associated with both the presence and extent of SCF.

Keyword

Coronary circulation; Mean platelet volume

MeSH Terms

Angiography
Arteries
Blood Platelets*
Coronary Angiography
Coronary Circulation
Humans
Infarction
Linear Models
Mean Platelet Volume
Multivariate Analysis

Figure

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  Fig. 1 Relationship between platelet volume indices MPV (A), PDW (B), P-LCR (C), and the extent of SCF. MPV: mean platelet volume, PDW: platelet distribution width, P-LCR: platelet larger cell ratio, SCF: slow coronary flow.

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  Fig. 2 Receiver operating characteristics curve analysis to detect the best cut-off values of platelet volume indices for differentiation between normal and slow coronary flows. AUC: area under the curve, CI: confidence interval, Sn: sensitivity, Sp: specificity, MPV: mean platelet volume, PDW: platelet distribution width, P-LCR: platelet larger cell ratio.

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