Korean Circ J.  2015 Nov;45(6):531-534. 10.4070/kcj.2015.45.6.531.

A Rare Cause of Secondary Hypertension in A Young Adult

• Choi JH
• Park TH
• Kim MH
• Kim YD
• Rhyou HI
• Rha SH
• Park KJ
• Woo JS

• KMID: 2223794
• DOI: http://doi.org/10.4070/kcj.2015.45.6.531

Abstract

Reninoma is a rare, renin-secreting, benign renal neoplasm that can cause secondary hypertension. We report a case of a 21-year-old man who suffered from progressively worsening headache for 2 months with a history of hypertension for 7 years. Laboratory studies showed normal potassium level, increased basal plasma renin activity, and normal serum aldosterone level. Abdominal computed tomography and magnetic resonance imaging revealed a small mass in the middle region of the right kidney. Partial nephrectomy was performed; immunohistochemical results demonstrated typical features of reninoma. Postoperatively, blood pressure and potassium level were normal at the 2-month follow-up.

Keyword

Hypertension; Kidney neoplasms; Nephrectomy

MeSH Terms

Aldosterone
Blood Pressure
Follow-Up Studies
Headache
Humans
Hypertension*
Kidney
Kidney Neoplasms
Magnetic Resonance Imaging
Nephrectomy
Plasma
Potassium
Renin
Young Adult*
Aldosterone
Potassium
Renin

Figure

• 

  Fig. 1 Computed tomography scan shows a well-defined mass of 1.7×1 cm (arrow) in the middle portion of right kidney.

• 

  Fig. 2 T2-weighted magnetic resonance imaging shows a small solid mass (arrow) in the right kidney middle pole.

• 

  Fig. 3 Gross examination revealed a well-defined ovoid mass with foci of hemorrhage (star) and cystic changes (arrows).

• 

  Fig. 4 Electron microscopy shows that tumor cells have typical rhomboid crystalline protogranules (stars) with electron dense bodies of different shapes (arrows).

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