J Rheum Dis.  2012 Apr;19(2):95-99. 10.4078/jrd.2012.19.2.95.

A Case of Rheumatoid Arthritis in a Patient with Bruton-Type Agammaglobulinemia

Affiliations
  • 1Department of Rheumatology, Chonnam National University Medical School, Gwangju, Korea. shinseok@chonnam.ac.kr
  • 2Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Bruton-type agammaglobulinemia is primary hypogammaglobulinemia followed by severe recurrent infection, including bacterial otitis media, bronchitis, pneumonia, and meningitis. Septic arthritis is a main musculoskeletal disorder that can occur in association with Bruton-type agammaglobulinemia. But the development of rheumatoid arthritis (RA) is rarely reported in a patient with hypogammaglobulinemia. Here, we describe a case of 34-year-old male with Bruton-type agammaglobulinemia, who presented with multiple symmetric polyarthritis. He was diagnosed as having a RA according to ACR criteria. His symptoms of polyarthritis had been improved after the introduction of medications including DMARDs (disease modifying anti-rheumatic drugs). Our case suggests that RA can be developed in the setting of agammaglobulinemia, and even in this situation, anti-rheumatic agents were effective to control arthritis without complication such as severe infection.

Keyword

Bruton-type agammaglobulinemia; Rheumatoid arthritis; Anti-rheumatic agents

MeSH Terms

Adult
Agammaglobulinemia
Antirheumatic Agents
Arthritis
Arthritis, Infectious
Arthritis, Rheumatoid
Bronchitis
Genetic Diseases, X-Linked
Humans
Male
Meningitis
Otitis Media
Pneumonia
Agammaglobulinemia
Antirheumatic Agents
Genetic Diseases, X-Linked
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