J Rheum Dis.  2014 Dec;21(6):340-342. 10.4078/jrd.2014.21.6.340.

Development of Crohn's Disease during Etanercept Treatment in Juvenile Idiopathic Arthritis

• Lee H
• Choe JY

• KMID: 2222942
• DOI: http://doi.org/10.4078/jrd.2014.21.6.340

Abstract

No abstract available.

MeSH Terms

Arthritis, Juvenile*
Crohn Disease*
Etanercept

Figure

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  Figure 1. Dynamic CT scan shows irregular mural thickening and enhancement in IC valve and terminal ileum in initial study (A), and much improved inflammation in follow-up study (B).

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  Figure 2. Endoscopic finding shows multiple various sized shallow ulcers with inflammatory polyposis at terminal ileum.

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  Figure 3. Light microscopy shows chronic inflammation with noncaseous granuloma.

Reference

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2. Wiegering V, Morbach H, Dick A, Girschick HJ. Crohn's disease during etanercept therapy in juvenile idiopathic arthritis: a case report and review of the literature. Rheumatol Int. 2010; 30:801–4.

3. Toussirot É, Houvenagel É, Goëb V, Fouache D, Martin A, Le Dantec P, et al. Le CRI. Development of inflammatory bowel disease during anti-TNF-α therapy for inflammatory rheumatic disease: a nationwide series. Joint Bone Spine. 2012; 79:457–63.

4. Sandborn WJ, Hanauer SB, Katz S, Safdi M, Wolf DG, Baerg RD, et al. Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2001; 121:1088–94.

5. Van den Brande JM, Braat H, van den Brink GR, Versteeg HH, Bauer CA, Hoedemaeker I, et al. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology. 2003; 124:1774–85.