Ann Rehabil Med.  2013 Jun;37(3):311-319. 10.5535/arm.2013.37.3.311.

Effect of the Presence of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on the Recovery in Patients With Acute Subcortical Stroke

• Kim WS
• Lim JY
• Shin JH
• Park HK
• Tan SA
• Park KU
• Paik NJ

• KMID: 2219527
• DOI: http://doi.org/10.5535/arm.2013.37.3.311

Abstract

OBJECTIVE
To investigate the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the recovery after subcortical stroke, using the modified Rankin Scale (mRS).
METHODS
Subcortical stroke patients with copies of BDNF Val66Met polymorphism (n=7) were compared to their controls (n=7) without a copy of BDNF Val66Met polymorphism after matching for initial severity, location and type of stroke. The mRS scores at 1 and 3 months after discharge from the neurorehabilitation unit were compared between the groups.
RESULTS
A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24) =37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), thereby reflecting significant differences between the Met allele (+) group and the Met allele (-) group. There was a significant difference in mRS scores at 3 months post-discharge between the two groups (p=0.01) although no difference was evident in mRS scores at 1 month post-discharge between the two groups. There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group.
CONCLUSION
BDNF Val66Met polymorphism may be associated with worse functional outcome in Korean patients with subcortical stroke. Therefore, BDNF Val66Met polymorphism should be considered as an important prognostic factor for recovery and responses to rehabilitation therapies after stroke in Korean patients. There is a need for developing different rehabilitation strategies for the population with BDNF Val66Met polymorphism. Further studies assessing different outcomes for various functional domains of stroke recovery are needed to clarify the role of BDNF Val66Met polymorphism.

Keyword

Brain-derived neurotrophic factor; Polymorphism; Stroke; Recovery; Brain plasticity

MeSH Terms

Alleles
Brain-Derived Neurotrophic Factor
Coat Protein Complex I
Humans
Stroke
Brain-Derived Neurotrophic Factor
Coat Protein Complex I

Figure

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  Fig. 1 Diffusion weighted magnetic resonance imaging and computed tomography scans (patient 5 and 5') in acute stage of stroke. Patient number with the apostrophe denotes matching of a patient in the Met allele (+) group to the patient with the same number in the Met allele (-) group.

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  Fig. 2 Modified Rankin Scale (mRS) on admission to the rehabilitation unit, at 1 month post-discharge and 3 months post-discharge according to the presence of the Met allele. *p<0.017 with Bonferroni correction by student's t-test, †p<0.025 with Bonferroni correction by paired t-test.

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