Allergy Asthma Respir Dis.  2016 Jan;4(1):31-37. 10.4168/aard.2016.4.1.31.

Significance of Malassezia-specific IgE in children with dermatitis involving the head and neck

Affiliations
  • 1Department of Pediatrics, Busan St. Mary's Hospital, Busan, Korea. sbdph1@daum.net

Abstract

PURPOSE
Even though Malassezia yeast may play an important role in the exacerbation of atopic dermatitis (AD), only a few studies of Malassezia infection have been conducted in children with AD. Thus, we compared each of clinical findings, including the severity of head and neck dermatitis and laboratory results depending on specific IgE against Malassezia furfur.
METHODS
This cross-sectional study was carried out on 121 children aged 3 months to 18 years between April and July of 2014. Retrospective data was collected using the medical records, and patients were divided into 2 groups according to the presence of Malassezia sensitization.
RESULTS
Specific IgE against Malassezia (group 1) was observed in 28 of all patients (23.1%). Group 1 children were at an older age (9.1+/-6.9 vs. 2.1+/-3.7, P<0.001). Group 1 children had a higher SCORing Atopic Dermatitis (SCORAD) index (46.4+/-21.0 ng/mL vs. 37.2+/-13.4 ng/mL, P=0.001), and total IgE (1,324.2+/-1,166.0 IU/mL vs. 209.5+/-532.5 IU/mL, P<0.001) compared to group 2 children (Malassezia-). In the group 1, the correlation between the Malassezia-specific IgE and 25-hydroxyvitamin D3 was negatively weak (r=-0.106) and not statistically significant (P=0.246). Furthermore, Malassezia-specific IgE and the SCORAD index (r=0.281, P=0.002) or total IgE (r=0.380, P<0.001) were positively correlated.
CONCLUSION
The results of this study suggest that specific IgE against M. furfur may be helpful in assessing the severity of prepubertal children and early adolescents with AD involving the head and neck.

Keyword

Atopic dermatitis; Malassezia; SCORAD index

MeSH Terms

Adolescent
Calcifediol
Child*
Cross-Sectional Studies
Dermatitis*
Dermatitis, Atopic
Head*
Humans
Immunoglobulin E*
Malassezia
Medical Records
Neck*
Retrospective Studies
Yeasts
Calcifediol
Immunoglobulin E

Figure

  • Fig. 1 The distribution of patients according to Malassezia furfur-specific IgE antibodies.

  • Fig. 2 Correlations of the level of 25-(OH)D (A), SCORAD index (B), and total IgE (C) to Malassezia furfur-specific IgE antibodies. P-value was applied by Pearson correlation. 25-(OH)D, 25-hydroxy vitamin D; sIgE, specific IgE; SCORAD, SCORing Atopic Dermatitis; ImmunoCAP (Phadia AB, Uppsala, Sweden).


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