J Korean Ophthalmol Soc.  2014 Sep;55(9):1277-1283. 10.3341/jkos.2014.55.9.1277.

Effects of Topical Tranilast on Corneal Haze with the Pentacam(R) after Photorefractive Keratectomy

• Kim SI
• Oh TH

• KMID: 2217109
• DOI: http://doi.org/10.3341/jkos.2014.55.9.1277

Abstract

PURPOSE
To evaluate the inhibitory effect of tranilast on formation of corneal haze using the Pentacam(R) after photorefractive keratectomy (PRK).
METHODS
A prospective, randomized, paired eye study was performed. A total of 60 eyes from 30 patients were enrolled in the present study. Eyes were categorized as myopic eyes <-5 D and > or =-5 D. Patients undergoing PRK were randomized to receive tranilast in one eye and no medication in the contralateral eye. Three months postoperatively, corneal haze was measured with the Pentacam(R) and compared between the 2 groups.
RESULTS
Statistical differences were not found in preoperative data in the tranilast or control groups (all P > 0.05). There was a strong decreasing density trend from the apex to the 3 mm radius in both groups (P < 0.05). However, postoperative corneal haze in the tranilast group was similar to the control group (P > 0.05).
CONCLUSIONS
The use of tranilast after PRK did not inhibit corneal opacity. Additionally, Pentacam(R) can provide a useful objective measure of corneal haze.

Keyword

Corneal haze; Pentacam(R); PRK; Tranilast

MeSH Terms

Corneal Opacity
Humans
Photorefractive Keratectomy*
Prospective Studies
Radius

Figure

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  Figure 1. Scheimpflug image and slit-lamp photograph of a cornea after PRK.

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  Figure 2. Correlation of corneal haze with distance from the apex for myopic eyes <- 5 D after photorefractive keratectomy (PRK) in tranilast (p < 0.05, r = −0.64).

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  Figure 3. Correlation of corneal haze with distance from the apex for myopic eyes <- 5 D after photorefractive keratectomy (PRK) in control (p < 0.05, r = −0.66).

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  Figure 4. Correlation of corneal haze with distance from the apex for myopic eyes ≥-5 D after photorefractive keratectomy (PRK) in tranilast (p < 0.05, r = −0.72).

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  Figure 5. Correlation of corneal haze with distance from the apex for myopic eyes ≥-5 D after photorefractive keratectomy (PRK) in control (p < 0.05, r = −0.69).

Reference

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