J Korean Ophthalmol Soc.  2012 Aug;53(8):1088-1098. 10.3341/jkos.2012.53.8.1088.

Changes in Higher-Order Aberrations after Penetrating Keratoplasty

• Sung MS
• Oh HJ
• Yoon KC

• KMID: 2215950
• DOI: http://doi.org/10.3341/jkos.2012.53.8.1088

Abstract

PURPOSE
To evaluate the changes in corneal higher-order aberrations (HOAs) after penetrating keratoplasty (PKP) and to investigate the factors affecting the changes in corneal HOAs.
METHODS
Forty-eight eyes of 48 patients with three different underlying diseases who underwent PKP were retrospectively reviewed. The changes in corneal higher-order aberrations (total root mean square (RMS), coma, trefoil, and spherical aberration) were evaluated with Pentacam (Oculus Inc., Dutenhofen, Germany) at 1, 3, 6, 12, and 18 months postoperatively. Sex, age, underlying disease, suturing method, trephine size of donor, and suture state were analyzed as factors affecting the HOAs changes.
RESULTS
Total RMS values in the PKP eyes were 1.67 +/- 0.49 microm at 1 month, 1.63 +/- 0.49 microm at 3 months, 1.64 +/- 0.51 microm at 6 months, 1.61 +/- 0.50 microm at 12 months, and 1.79 +/- 0.40 microm at 18 months after surgery (p < 0.01). The values were higher compared with those in the control eyes. Sex, donor trephine size and suture method did not correlate with the HOAs changes. The HOAs in the keratoconus group were higher than those in the corneal opacity group or bullous keratopathy group. At 18 months, HOAs in the suture removed group were higher than those in the suture-remaining group.
CONCLUSIONS
Corneal HOAs after PKP were persistently higher than those in the control eyes. The HOAs were higher in patients with keratoconus and in the suture-removed group.

Keyword

Higher-order aberration; Penetrating keratoplasty

MeSH Terms

Coma
Corneal Opacity
Eye
Humans
Keratoconus
Keratoplasty, Penetrating
Lotus
Retrospective Studies
Sutures
Tissue Donors

Figure

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  Figure 1 Changes in best corrected visual acuity (A), mean keratometric power (B), spherical equivalent (C) after penetrating keratoplasty. D = diopter. *p < 0.05 compared with other periods, repeated measures ANOVA.

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  Figure 2 The changes of higher-order aberrations in the penetrating keratoplasty and control group. RMS = root mean square; PKP = penetrating keratoplasty. *p < 0.01 compared with the control group, paired t-test; †p < 0.05 compared with other periods, repeated measures ANOVA.

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  Figure 3 Correlation between age and higher-order aberrations including total RMS, coma, trefoil and spherical aberration at 12 months after penetrating keratoplasty. RMS = root mean square.

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  Figure 4 Comparison of the higher-order aberrations after penetrating keratoplasty according to the original diseases. RMS = root mean square. *p < 0.05 compared with the keratitis group; †p < 0.05 compared with the bullous keratopathy group, Kruskall-W allis test followed by Mann-Whitney U test with Bonfferoni correction.

• 

  Figure 5 Comparison of the higher-order aberrations after penetrating keratoplasty according to the suture state at postoperative 18 months. RMS = root mean square. *p < 0.05 campared with the group that suture remained, Mann-Whitney U test.

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