J Korean Ophthalmol Soc.  2011 Jan;52(1):34-40. 10.3341/jkos.2011.52.1.34.

Long-term Therapeutic Effect of Intravitreal Bevacizumab (Avastin) on Myopic Choroidal Neovascularization

• Seo YS
• Chang MH

• KMID: 2214135
• DOI: http://doi.org/10.3341/jkos.2011.52.1.34

Abstract

PURPOSE
To evaluate the long-term therapeutic effects of intravitreal bevacizumab on myopic choroidal neovascularization (CNV).
METHODS
Medical records of 6 patients who underwent intravitreal bevacizumab injection for myopic CNV and were followed for more than 2 years, were retrospectively investigated. The best corrected visual acuity was compared at 1,3,12, and 24 months after injection. Two years after the injection, a fluorescein angiography and optical coherence tomography (OCT) were performed to evaluate the central macular thickness and leakage of CNV.
RESULTS
The mean best corrected visual acuity was 1.16 +/- 0.43 (logMAR), 0.45 +/- 0.21 (logMAR), 0.29 +/- 0.23 (logMAR), 0.14 +/- 0.11 (logMAR), and 0.11 +/- 0.06 (logMAR) at baseline, 1, 3, 12, and 24 months after injection, respectively.
CONCLUSIONS
Intravitreal bevacizumab injection for the treatment of myopic CNV was effective in maintaining postoperative visual acuity for 2 years.

Keyword

Bevacizumab; Choroidal neovascularization; Intravitreal injection; Long-term; Myopic CNV

MeSH Terms

Antibodies, Monoclonal, Humanized
Choroid
Choroidal Neovascularization
Fluorescein Angiography
Humans
Intravitreal Injections
Medical Records
Retrospective Studies
Tomography, Optical Coherence
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized

Figure

• 

  Figure 1. Mean best corrected visual acuity at baseline, 1, 3, 12, and 24 months. After intravitreal bevacizumab injection, graph shows to maintenance of good visual acuity until 2 years later (p = 0.042, p = 0.028, p = 0.042, p = 0.028, Wilcoxon signed rank test).

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  Figure 2. Best corrected visual acuity in each of six cases. Most cases maintain improved visual acuity until 2 years later.

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  Figure 3. CMT at preinjection and 2-years later after injection. Graph shows to maintenance of decreased central macular thickness until 2 years later (p = 0.01, Wilcoxon signed rank test).

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  Figure 4. Serial fundus photographs and fluorescein angiographs and optical coherence tomographs of case 6. (A) images before intravitreal bevacizumab injection showed subfoveal hemorrhage and juxtafoveal classic CNV and macular edema. At this time BCVA was 0.02 (logMAR 1.70). At 1 year after intravitreal bevacizumab injection, (B) images showed scar change of CNV membrane and just fluorescein staining without fluorescein leakage. BCVA at 1 year was 1.0 (logMAR 0.00). At 2 years after intravitreal bevacizumab injection, (C) images showed similar findings at (B) images. BCVA at 2 year was 0.9 (logMAR 0.04). Until two years later, very good and stable prognosis has been shown.

Reference

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