J Korean Ophthalmol Soc.  2010 Jul;51(7):935-940. 10.3341/jkos.2010.51.7.935.

Comparison of the Effects of Prophylactic Nonsteroidal Anti-inflammatory Drugs on Macular Edema After Cataract Surgery

• Chun BY
• Kang SY
• Song JS
• Kim HM

• KMID: 2213758
• DOI: http://doi.org/10.3341/jkos.2010.51.7.935

Abstract

PURPOSE
To evaluate and compare the efficacy of prophylactic administration of topical nonsteroidal anti-inflammatory (NSAID) drugs on macular edema (ME) following cataract surgery.
METHODS
The present open-label non-masked randomized (random number assignment) study was comprised of 90 eyes. Thirty eyes were administered Diclofenac sodium 0.1%, and 30 eyes were administered Pranoprofen 0.1% starting three days before surgery and continued for one month after surgery. The remaining 30 eyes made up the control group. The results consisted of the measurements of foveal thickness (FT), macular thickness (MT), and total macular volume (TMV), which were quantified by optical coherence tomography (OCT, Carl Zeiss Meditec) before and one month after phacoemulsification surgery.
RESULTS
At one month, there were statistically significant differences in FT in the Diclofenac group (0.48+/-10.9 micrometer) and the Pranoprofen group (1.87+/-14.7 micrometer) (p<0.05) compared with the control group (11.65+/-18.6 micrometer). In addition, there was a statistically significant difference in MT between the control group (71.06+/-90.8 micrometer) and the Diclofenac group (15.19+/-36.1 micrometer) (p<0.05). However, no statistical difference in MT was noted between the control group and the Pranoprofen group (27.57+/-70.93 micrometer). Between the control group and the NSAID groups, only the Diclofenac group showed statistical differences in TMV throughout the observational period.
CONCLUSIONS
Used prophylactically after cataract surgery, the NSAIDS eye drops were effective in reducing postoperative ME.

Keyword

Nonsteroidal anti-inflammatory drug (NSAID); Pseudophakic macular edema

MeSH Terms

Anti-Inflammatory Agents, Non-Steroidal
Benzopyrans
Cataract
Diclofenac
Eye
Macular Edema
Ophthalmic Solutions
Phacoemulsification
Propionates
Tomography, Optical Coherence
Anti-Inflammatory Agents, Non-Steroidal
Benzopyrans
Diclofenac
Ophthalmic Solutions
Propionates

Reference

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