J Korean Surg Soc.  2010 Nov;79(5):411-414. 10.4174/jkss.2010.79.5.411.

Extraskeletal Ewing's Sarcoma of the Breast, Mimicking Cyst

  • 1Department of Plastic and Reconstructive Surgery, Inha University School of Medicine, Incheon, Korea.
  • 2Department of Radiology, Inha University School of Medicine, Incheon, Korea. kimyj@inha.ac.kr
  • 3Department of Pathology, Inha University School of Medicine, Incheon, Korea.
  • 4Department of Surgery, Inha University School of Medicine, Incheon, Korea.


Extraskeletal Ewing' sarcoma (EES) is a rare soft tissue tumor morphologically indistinguishable from the osseous Ewing's sarcoma (ES). We report a case of recurrent EES of the breast that, to the best of our knowledge, has rarely been reported. It was initially confused for a cyst on ultrasound. In addition, MRI and breast-specific gamma imaging (BSGI) in our case have complementary value over conventional imaging.


Primitive neuroectodermal tumor; Ewing's sarcoma; Breast

MeSH Terms

Neuroectodermal Tumors, Primitive
Sarcoma, Ewing


  • Fig. 1 Primary Ewing's sarcoma of the breast in a 35-year-old woman. (A) Sonography showed a 2 cm, well-circumscribed, oval anechoic mass with posterior enhancement at the 12 o'clock position, 2 cm from the nipple. (B) Maximum intensity projection (MIP) image showed remained, smooth marginated, strong enhancing mass with increased vascularity after IV gadopentetate dimeglumine. (C) The mass showed hyperintense lesion on T2-weighted image. (D) MR spectroscopic image demonstrated elevated choline peak at 3.2 ppm. (E) Breast-specific gamma imaging (BSGI) showed hot uptake in upper inner quadrant (arrow). (F) Immunohistochemically, the lesion is composed of solid sheets of primitive or undifferentiated small round cells (H&E stain, ×200).


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