J Korean Ophthalmol Soc.  2007 Jan;48(1):91-96.

The Usefulness of the Uniocular Drug Trial in the Glaucoma Eyes

• Shin HH
• Yoo CK
• Choi YJ
• Kim YY

Abstract

PURPOSE: This study was undertaken to evaluate if the reduction of intraocular pressure (IOP) observed in a uniocular trial correlates with an IOP reduction observed in the fellow eye.
METHODS
The study was performed on forty patients with bilateral glaucoma or suspect glaucoma who underwent a uniocular trial of 0.005% latanoprost and subsequently received the same drug in the fellow eye after 1 week. Inter-eye IOP variations were less than 3 mm Hg over two measurements, and were followed minimally for 4 weeks. The uniocular IOP reduction (IOP before medication - IOP after medication) and the net IOP reduction (IOP change in the trial eye after medication - IOP change in the fellow eye) were calculated. The uniocular IOP reduction and net IOP reduction in the trial eye was compared with the results from the fellow eye.
RESULTS
The mean uniocular IOP reduction in the trial eye and the fellow eye were 3.6+/-2.42 mm Hg and 2.78+/-2.16 mm Hg, respectively (r=0.390, r2=0.152, P=0.013). The mean net IOP reduction in the trial eye and the opposing eye were 3.55+/-1.70 mm Hg and 3.15+/-1.83 mm Hg, respectively (r=0.782, r2=0.612, P=0.000).
CONCLUSIONS
A uniocular drug trial in patients with similar IOPs between their eyes can adequately predict the IOP lowering effect of a medication.

Keyword

Net IOP reduction; Uniocular drug trial; Uniocular IOP reduction

MeSH Terms

Glaucoma*
Humans
Intraocular Pressure
Ocular Hypertension