J Korean Soc Radiol.  2010 Jan;62(1):23-28. 10.3348/jksr.2010.62.1.23.

The Efficacy of Iopamidol (Pamiray 370(R)) in Aortic and Extremity CT Angiography

• Lee Y
• Lee J
• Lee HJ
• Park J

• KMID: 2208990
• DOI: http://doi.org/10.3348/jksr.2010.62.1.23

Abstract

PURPOSE
To evaluate the clinical safety and radiological feasibility of a domestic iopamidol-based contrast media (Pamiray(R)370) during an aortic and extremity CT angiography.
MATERIALS AND METHODS
Between August and December of 2008, 100 patients (M:F=51:49; mean age, 59 years) underwent an aortic and extremity CT angiography using Pamiray(R)370 based with informed consent. All changes in vital signs, clinical symptoms, and adverse reactions to the contrast media were monitored. Two radiologists assessed the image quality of the CT angiography. A statistical comparison was conducted using an independent t-test and a Mann-Whitney test based on the 100-patient group studied using Optiray(R)350.
RESULTS
The contrast enhancement of the descending aorta in the arterial phase showed a statistically greater efficacy (p<0.001) of Pamiray(R)370 compared to Optiray(R)350, which was the routine contrast media for CT angiography for our institute. Adverse reaction signs were evident in 3%(3/100) of the subjects. All of them showed mild and transient reactions such as vomiting (n=2) and coughing (n=1), with no medical treatment required. Contrast media related symptoms including dizziness (n=7), nausea (n=3), headaches (n=2), and injection site pain (n=1), were noted in 12%(12/100). CONCLUSION: The clinical efficacy of Pamiray(R)370 was acceptable for the aortic and extremity CT angiography, in terms of clinical safety, tolerance, and image quality.

MeSH Terms

Angiography
Aorta, Thoracic
Contrast Media
Cough
Dizziness
Extremities
Headache
Humans
Informed Consent
Iopamidol
Nausea
Tomography, X-Ray Computed
Vital Signs
Vomiting
Contrast Media
Iopamidol

Figure

• 

  Fig. 1 Comparison of descending aortic enhancement in DVT CT using Pamiray®370 (A) and Optiray®350 (B). (A) Contrast enhancement of descending aorta at pulmorary artery bifurication level is measured as 311.23 HU in the patient whom Pamiray®370 was injected. (B) A CT aortogram using Optiray®350 shows descending aortic enhancement of 265.97 HU

Reference

1. Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K. Adverse reactions to ionic and nonionic contrast media. A report from the japanese committee on the safety of contrast media. Radiology. 1990; 175:621–628.

2. Korn WT, Bettmann MA. Low-osmolality versus high-osmolality contrast material. Curr Opin Radiol. 1992; 4:9–15.

3. Bettmann MA, Heeren T, Greenfield A, Goudey C. Adverse events with radiographic contrast agents: results of the SCVIR contrast agent registry. Radiology. 1997; 203:611–620.

4. Grainger RG. Osmolality of intravascular radiological contrast media. Br J Radiol. 1980; 53:739–746.

5. Grainger RG. Intravascular contrast media. Br J Radiol. 1982; 55:544.

6. McClennan BL, Stolberg HO. Intravascular contrast media. Ionic versus nonionic: current status. Radiol Clin North Am. 1991; 29:437–454.

7. Wolf GL, Arenson RL, Cross AP. A prospective trial of ionic vs nonionic contrast agents in routine clinical practice: comparison of adverse effects. AJR Am J Roentgenol. 1989; 152:939–944.

8. Ringel K, Kuehn J. A double-blind study comparing the safety, tolerability, and efficacy of ioversol 320 and iopamidol-300 in cerebral angiography. Invest Radiol. 1989; 24:Suppl 1. S48–S51.

9. Bannon KR, Braun IF, Pinto RS, Manuell M, Sudilovsky A, Kricheff II. Comparison of radiographic quality and adverse reactions in myelography with iopamidol and metrizamide. AJNR Am J Neuroradiol. 1983; 4:312–313.

10. Voeltz MD, Nelson MA, McDaniel MC, Manoukian SV. The important properties of contrast media: focus on viscosity. J Invasive Cardiol. 2007; 19(3):1A–9A.

11. Conroy RM, Bjartveit K, Sheppick A, Long U, Masterson J. Iodixanol in intravenous urography: a comparison of iodixanol 270 mgI/ml, iodixanol 320 mgI/ml and iopamidol 300 mgI/ml (NIOPAM). Clin Radiol. 1994; 49:337–340.

12. Lee JW, Kim TK, Kim SH, Kim HB, Kim SH, Hwang SI, et al. Efficacy of Pamiray(R) as a Nonionic Intravenous Contrast Material: Experimental Study Using Normal Rabbits. J Korean Radiol Soc. 2000; 42:379–385.

13. Park SH, Suh SH, Kim J, Kim EY, Kim DJ, Lee SK, et al. Cinical Application of Iopamidol (Pamiray(R) 300) for Cerebral Angiography. J Korean Radiol Soc. 2007; 57:121–127.

14. Choi YH, Chung JW, Choi GM, Yoon CJ, Kim SH, Moon SG, et al. Paired comparison of iopamidol and iopromide in hepatic arteriography. J Korean Radiol Soc. 2003; 48:141–145.

15. Seo DC. Handbook of neurointerventional angiography. Seoul: Korea Medical Book Publisher;2001. p. 284. appendix 6.

16. Pollack HM. History of iodinated contrast media. In : Thomsen HS, Muller RN, Mattrey RF, editors. Trends in contrast media. Berlin: Springer;1999. p. 1–19.

17. Cochran ST, Bomyea K, Sayre JW. Trends in adverse events after IV administration of contrast media. AJR Am J Roentgenol. 2001; 176:1385–1388.