J Korean Pediatr Soc.
2002 Sep;45(9):1150-1154.
Two Cases of Wolff-Parkinson-White Syndrome in a Family
- Affiliations
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- 1Department of Pediatrics, Medical School, Chonbuk National University, Jeonju, Korea. joocu@moak.chonbuk.ac.kr
- 2Institute of Cardiovascular Research, Jeonju, Korea.
Abstract
- Wolff-Parkinson-White(WPW) syndrome is characterized by electrographic evidence of ventricular preexcitation, which predisposes to supraventicular arrhythmias. Familial occurrence of WPW syndrome is uncommon. We observed two affected siblings in a family. Five members of the family underwent 12-lead electrocardiography and echocardiography. Although known genetic abnormality of the 7q34-q36(PRKAG2) for the familial WPW syndrome was evaluated, the mutation was not detected in this family. Other unknown mutations responsible for this familial WPW syndrome were suggested.
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