J Korean Surg Soc.
1999 Jul;57(1):81-85.
Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinomas
- Affiliations
-
- 1Department of Surgery, Ajou University School of Medicine, Suwon, Korea.
- 2Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
Abstract
-
BACKGROUND: A tumor must continuously stimulate the growth of new capillary blood vessels for the tumor itself to grow and metastasize. Vascular endothelial growth factor (VEGF) promotes vascular permeability and endothelial cell growth. A hepatocellular carcinoma (HCC) is a typical hypervascular tumor.
METHODS
We evaluated the expression of VEGF in 36 cases of HCC by using immunohistochemical staining in order to define its prognostic value.
RESULTS
The expression rate of VEGF was 44.4% (16/36) in tumor cells and 0% (0/36) in non- tumorous liver parenchyme. VEGF expression did not correlate with any clinicopathological characteristics. And patients with expression of VEGF in tumor cells had no survival difference in comparison to those without VEGF expression.
CONCLUSIONS
These results suggest that the expression of VEGF in HCC cells by itself may not be a significant factor in the prognosis of HCC.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Expression of Vascular Endothelial Growth Factor (VEGF) and Microvessel Density in Hepatocellular Carcinoma
- Expression of Vascular Endothelial Growth Factor (VEGF) in Papillary Thyroid Carcinoma
- Expression of Vascular Endothelial Growth Factor : Clinical Implications in Cervical Neoplasia
- Vascular Endothelial Growth Factor and basic Fibroblast Growth Factor Expression in Early Gastric Carcinomas: Correlation with Clinicopathologic Factors
- Serum Vascular Endothelial Growth Factor in Hepatocellular Carcinoma
