J Korean Ophthalmol Soc.  2002 Dec;43(12):2489-2493.

The Complications Developed after Repeated Botulinum Toxin Injection

• Im CY
• Han SH
• Lee JB

Abstract

PURPOSE: To investigate the incidence of complication associated with repeated botulinum toxin chemodenervation in extraocular muscle.
METHODS
47 patients who had taken botulinum toxin chemodenervation from 1996 to November 2001 were reviewed retrospectively. 10 patients had taken repeated injection. Saline diluted botulinum toxin was directly injected into the extraocular muscle through the Teflon coated needle.
RESULTS
In 10 patients, 5 patients had complications which were 2 cases of hypertropia, 2 cases of ptosis and 1 case of retrobulbar hemorrhage who was 44 year old woman taken 5 times of botulinum toxin injection. She was successfully treated with lateral canthotomy and cantholysis.
CONCLUSIONS
Rate of complication in repeated botulinum toxin chemodenervation was not different from that of single procedure. We experienced one case of retrobulbar hemorrhage in 10 patients with repeated botulinum injection.

Keyword

Botulinum toxin injection; Repeated injection; Retrobulbar hemorrhage

MeSH Terms

Adult
Botulinum Toxins*
Female
Humans
Incidence
Needles
Nerve Block
Polytetrafluoroethylene
Retrobulbar Hemorrhage
Retrospective Studies
Strabismus
Botulinum Toxins
Polytetrafluoroethylene