J Korean Ophthalmol Soc.  1999 Mar;40(3):772-778.

The Effects of 2% Dorzolamide(Trusopt) and 0.12% UF-021(Rescula)on Intraocular Pressure and Peripapillary Retinal and Optic Nerve Head Microcirculation

• Woo JH
• Park WC
• Rho SH

Abstract

We investigated the effect of 2% dorzolamide and 0.12% UF-021 on intraocular pressure and peripapillary and optic nerve head microcirclation with Heidelberg Retina Flowmeter. The 40 eyes of 40 normal subjects were divided 2 groups. 2% Borzolamide and 0.12% UF-021 were instilled in each group. The IOP and microcirculation of peripillary retina and optic nerve head were measured before and 90min, 4, 8, 12, 24 hours after instillation. The IOP was decreased at 90 minutes, 4, 8 hours after instillation of 2% dorzolamide and maximal reduction of IOP was observed at 90 minutes (P<0.05). The IOP was decreased at 90min, 4, 8, 12 hours after instillation of 0.12% UF-021 and maximal reduction of IOP was observed at 4 hours(P<0.05). But, there was no statistically significant changes of microciculation in both groups(P>0.05). We suggest that 2% dorzolamide and 0.12% UF-021 reduce the IOP, but do not alter the mictocirculation of peripapillary retina and optic nerve head.

Keyword

Dorzolamide; Heidelberg Retina Flowmeter; Intraocular pres-sure; Retinal and optic nerve head microcirculation; UF 021

MeSH Terms

Flowmeters
Intraocular Pressure*
Microcirculation
Optic Disk*
Optic Nerve*
Retina
Retinaldehyde*
Retinaldehyde