J Korean Soc Plast Reconstr Surg.  2006 Nov;33(6):757-760.

Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Report

• Yoo JS
• Lee DL
• Lim JK
• Yoon IM
• Lee BD
• Lee DE

Abstract

PURPOSE: Anaplastic large cell lymphoma, has the following three characteristics of a malignant lymphoma; 1) An irregular large nucleus, called pathologic atypical cells, 2) Eosinophilic cytoplasm, 3) Immunologically positive for Ki-1. Anaplastic large cell lymphoma occurs mostly in the lymph nodes, but about 40% has been observed to occur in other tissues. Skin is the one of the main sources of origin and it is called 'primary cutaneous anaplastic large cell lymphoma'.
METHODS
A 69-year-old male patient with an erythematous nodule, sized 1.5 X 1.7 cm on his right hand dorsum was excised under local anesthesia and on biopsy was diagnosed as 'Dermatofibrosarcoma Protuberans'. Three months after the local excision and biopsy, same natured mass reoccurred in the same region, and then spontaneous regressed after three weeks. However, metastatic large mass of 4.0 X 5.0 cm, of same nature was observed on the elbow. The large mass was operated with wide excision and biopsy.
RESULTS
On final diagnosis, with an immunofluorescent stain with CD30(Ki-1), 'Primary cutaneous large cell lymphoma' was made. After follow up for three years, we did not observed recurrence and metastasis.
CONCLUSION
We have reported that we have diagnosed primary cutaneous large cell lymphoma and treated without recurrence and metastasis.

Keyword

Lymphoma; Large-cell; Ki-1; CD30

MeSH Terms

Aged
Anesthesia, Local
Biopsy
Cytoplasm
Diagnosis
Elbow
Eosinophils
Follow-Up Studies
Hand
Humans
Lymph Nodes
Lymphoma
Lymphoma, Large-Cell, Anaplastic
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
Male
Neoplasm Metastasis
Recurrence
Skin