J Korean Rheum Assoc.  2009 Mar;16(1):59-63. 10.4078/jkra.2009.16.1.59.

A Case of Dermatomyositis Associated with Prostate Cancer

• Kim HY
• Kwok SK
• Kim WU

• KMID: 2202143
• DOI: http://doi.org/10.4078/jkra.2009.16.1.59

Abstract

Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous lesions and progressive symmetric proximal muscle weakness. An association between dermatomyositis and malignancy has long been reported on. A 73 year-old male patient with had biopsy-proven prostate cancer presented with typical skin lesions and proximal muscle weakness. On the laboratory findings, the muscle enzymes were prominently elevated. EMG and muscle biopsy showed typical findings that were consistent with dermatomyositis. The patient was successfully treated with systemic steroid, intravenous immunoglobulin and methotrexate. In Korea, dermatomyositis is frequently complicated by stomach, lung and breast cancers. To the best of our knowledge, this is the first Korean report of dermatomyositis accompanied by prostate cancer. Here, we describe the case of dermatomyositis with prostate cancer and we briefly review the relevant literatures.

Keyword

Dermatomyositis; Prostate cancer; Malignancy

MeSH Terms

Biopsy
Breast
Dermatomyositis
Humans
Immunoglobulins
Korea
Lung
Male
Methotrexate
Muscle Weakness
Muscles
Myositis
Prostate
Prostatic Neoplasms
Skin
Stomach
Immunoglobulins
Methotrexate

Figure

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  Fig. 1. (A) Malar erythema involving the nasolabial fold and erythematous poikiloderma on the upper chest (the “V” sign). (B) Pruritic erythematous poikiloderma on the upper back (the shawl sign).

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  Fig. 2. Histology of the skeletal muscle from the gluteus medius muscle shows perivascular (arrow) and interfascicular lymphohistiocyte infiltrations with polymorphonuclear leukocytes, and these findings are suggestive of inflammatory myopathy (H&E stain, ×200).

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