J Korean Soc Transplant.  2006 Dec;20(2):181-186.

Experience of Simultaneous Pancreas and Kidney Transplantation in Seoul National University Hospital

• Park JW
• Ha J
• Lee JH
• Kang JM
• Jung SK
• Kim EM
• Lee HS
• Kim YS
• Cho YM
• Park KS
• Ahn C
• Kim SJ

Abstract

Purpose: Aim of this study is to review the simultaneous pancreas and kidney transplantation (SPK) cases performed in Seoul National University Hospital for DM nephropathy patients.
Methods
Medical records of the SPK recipients from April 2002 to February 2006 were reviewed and analyzed retrospectively. Results: There were 10 cases of SPK transplantation in SNUH from April 2002 to February 2006, which were composed of 8 type II DM patients and 2 type I DM patients. We experienced 1 operative mortality case and 3 acute rejection cases. All the acute rejection cases were recovered by steroid pulse therapy. We performed two graft pancreatectomy operations due to CMV infection followed by duodenal perforation and severe graft pancreatitis with pancreatic leakage. With the exception of 1 mortality case and 2 graft loss cases, all 7 patients stopped insulin and oral hypoglycemic agent and are keeping blood glucose level within normal range.
Conclusion
Although patient follow-up is limited up to four years, SPK recipients are free from insulin use and show good graft functions. SPK could be a good treatment modality for insulin dependent type II DM nephropathy patients.

Keyword

Pancreas transplantation; Kidney transplantation; Diabetes mellitus; ESRD (end-stage renal disease); Immunosuppressive agents

MeSH Terms

Blood Glucose
Diabetes Mellitus
Follow-Up Studies
Humans
Immunosuppressive Agents
Insulin
Kidney Transplantation*
Kidney*
Medical Records
Mortality
Pancreas Transplantation
Pancreas*
Pancreatectomy
Pancreatitis, Graft
Reference Values
Retrospective Studies
Seoul*
Transplants
Blood Glucose
Immunosuppressive Agents
Insulin