J Menopausal Med.  2015 Apr;21(1):12-18. 10.6118/jmm.2015.21.1.12.

A Flood of Health Functional Foods: What Is to Be Recommended?

• Lee ES

• KMID: 2201016
• DOI: http://doi.org/10.6118/jmm.2015.21.1.12

Abstract

Health functional food is referred to a food prepared or processed from specific components or ingredients for functionality beneficial to the body through extraction, concentration, purification, blending and other methods. The demand for health functional foods is steadily increasing, and red ginseng is the most demanded food among women in the 50s, followed by multivitamin, omega-3, glucosamine and aloe. To date, there is insufficient evidence on the effect of red ginseng on exercise capacity, somatic symptom and cognitive performance in healthy individuals. Moreover, evidence is insufficient that a nutritional dose of vitamin or mineral reduces the incidence of cardiovascular disease and cancer, or mortality rate. A steady intake of oily fish is recommended to prevent the incidence of cardiovascular disease for postmenopausal women. Consumption of omega-3 fatty acids is expected to prevent cardiovascular disease in postmenopausal women with almost no intake of oily fish and those not taking statins. It still remains controversial whether glucosamine is effective in the treatment of osteoarthritis. Hence, physicians should fully inform patients with all controversial information about the effectiveness of glucosamine when prescribing glucosamine for patients with osteoarthritis.

Keyword

Fatty acids omega-3; Functional foods; Glucosamine; Red ginseng; Vitamins

MeSH Terms

Aloe
Cardiovascular Diseases
Fatty Acids, Omega-3
Female
Functional Food*
Glucosamine
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Incidence
Mortality
Osteoarthritis
Panax
Vitamins
Fatty Acids, Omega-3
Glucosamine
Vitamins

Reference

1. Korea Agency of Education, Promotion & Information Service in Food, Agriculture, Forestry & Fisheries. Patent analysis report of health functional foods. . Anyang: Korea Agency of Education, Promotion & Information Service in Food, Agriculture, Forestry & Fisheries;2014.

2. Korea Agro-Fisheries & Food Trade Corporation. 2013 health functional food market report. Naju: Korea Agro-Fisheries & Food Trade Corporation;2013.

3. Heo J, Park Y, Park HM. Dietary intake of nutrients and food in postmenopausal Korean women. J Korean Soc Menopause. 2011; 17:12–20.

4. Choi J, Kim TH, Choi TY, Lee MS. Ginseng for health care: a systematic review of randomized controlled trials in Korean literature. PLoS One. 2013; 8:e59978.

5. Hwang H, Kim J, Park J, Yun H, Cheon WK, Kim B, et al. Red ginseng treatment for two weeks promotes fat metabolism during exercise in mice. Nutrients. 2014; 6:1874–1885.

6. Lee JS, Hwang HS, Ko EJ, Lee YN, Kwon YM, Kim MC, et al. Immunomodulatory activity of red ginseng against influenza A virus infection. Nutrients. 2014; 6:517–529.

7. Yin SY, Kim HJ, Kim HJ. A comparative study of the effects of whole red ginseng extract and polysaccharide and saponin fractions on influenza A (H1N1) virus inefction. Biol Pharm Bull. 2013; 36:1002–1007.

8. Oh MR, Park SH, Kim SY, Back HI, Kim MG, Jeon JY, et al. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. BMC Complement Altern Med. 2014; 14:237.

9. de Andrade E, de Mesquita AA, Claro Jde A, de Andrade PM, Ortiz V, Paranhos M, et al. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian J Androl. 2007; 9:241–244.

10. Lee NH, Son CG. Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng. J Acupunct Meridian Stud. 2011; 4:85–97.

11. Kim SO, Kim MK, Lee HS, Park JK, Park K. The effect of Korean red ginseng extract on the relaxation response in isolated rabbit vaginal tissue and its mechanism. J Sex Med. 2008; 5:2079–2084.

12. Oh KJ, Chae MJ, Lee HS, Hong HD, Park K. Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study. J Sex Med. 2010; 7:1469–1477.

13. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993; 85:1483–1492.

14. Qiao YL, Dawsey SM, Kamangar F, Fan JH, Abnet CC, Sun XD, et al. Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. J Natl Cancer Inst. 2009; 101:507–518.

15. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004; 164:2335–2342.

16. Hercberg S, Kesse-Guyot E, Druesne-Pecollo N, Touvier M, Favier A, Latino-Martel P, et al. Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: a postintervention follow-up in the SU.VI.MAX Study. Int J Cancer. 2010; 127:1875–1881.

17. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2008; 300:2123–2133.

18. Prentice RL. Clinical trials and observational studies to assess the chronic disease benefits and risks of multivitamin-multimineral supplements. Am J Clin Nutr. 2007; 85:308S–313S.

19. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993; 328:1444–1449.

20. Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998; 279:359–364.

21. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008; CD007176.

22. Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2013; 159:824–834.

23. Deckelbaum RJ, Torrejon C. The omega-3 fatty acid nutritional landscape: health benefits and sources. J Nutr. 2012; 142:587S–591S.

24. Sudheendran S, Chang CC, Deckelbaum RJ. N-3 vs. saturated fatty acids: effects on the arterial wall. Prostaglandins Leukot Essent Fatty Acids. 2010; 82:205–209.

25. Miles JM, Park YS, Walewicz D, Russell-Lopez C, Windsor S, Isley WL, et al. Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids. Diabetes. 2004; 53:521–527.

26. Stone NJ. Fish consumption, fish oil, lipids, and coronary heart disease. Circulation. 1996; 94:2337–2340.

27. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM, Albert CM, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA. 2002; 287:1815–1821.

28. Iso H, Rexrode KM, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA. 2001; 285:304–312.

29. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007; 369:1090–1098.

30. Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012; 308:1024–1033.

31. Lewis EJ. Omega-3 fatty acid supplementation and cardiovascular disease events. JAMA. 2013; 309:27.

32. DiNicolantonio JJ, Niazi AK, McCarty MF, O'Keefe JH, Meier P, Lavie CJ. Omega-3s and cardiovascular health. Ochsner J. 2014; 14:399–412.

33. Kim TH, Byun DW, Park Y. Omega-3 and menopause. J Korean Soc Menopause. 2012; 18:75–80.

34. Dahmer S, Schiller RM. Glucosamine. Am Fam Physician. 2008; 78:471–476.

35. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005; CD002946.

36. D'Ambrosio E, Casa B, Bompani R, Scali G, Scali M. Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica. 1981; 2:504–508.

37. Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001; 357:251–256.

38. Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002; 162:2113–2123.

39. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006; 354:795–808.

40. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica. 1982; 3:157–168.