J Korean Soc Endocrinol.  2005 Jun;20(3):268-272. 10.3803/jkes.2005.20.3.268.

A Case of Thyroid MALT Lymphoma without Autoimmune Thyroiditis

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea.
  • 2Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.

Abstract

A primary thyroid lymphoma is rare among all types of thyroid malignancy. Usually, a thyroid lymphoma is associated with underlying chronic autoimmune thyroiditis. Recently, we experienced a primary thyroid mucosa-associated lymphoid tissue(MALT) lymphoma, with an incidental micropapillary thyroid carcinoma, but lacking evidence of autoimmune thyroiditis. A female patient visited our hospital for further evaluation of a rapidly enlarging, painless thyroid mass which had been stable for 8 years. Lymphocytic thyroiditis or a lymphoma was suspected from fine needle aspiration performed at another hospital. The thyroid function test and other routine laboratory tests were normal. The histopathological findings after a total thyroidectomy revealed a MALT lymphoma with a micropapillary thyroid carcinoma. There was no evidence of chronic autoimmune thyroiditis. This is, to the best of our knowledge, the first case report of a MALT lymphoma arising from the thyroid gland without evidence of chronic autoimmune thyroiditis in Korea


MeSH Terms

Biopsy, Fine-Needle
Female
Humans
Korea
Lymphoma
Lymphoma, B-Cell, Marginal Zone*
Thyroid Function Tests
Thyroid Gland*
Thyroid Neoplasms
Thyroidectomy
Thyroiditis, Autoimmune*

Figure

  • Fig. 1 Computed tomography of the neck shows soft tissue mass in isthmus of thyroid gland (arrow)

  • Fig. 2 Sections from thyroid gland showing proliferation of multiple lymphoid follicles with intervening thyroid follicular epithelial cells (H-E, ×40)

  • Fig. 3 Atypical lymphoid cells infiltrating thyroid follicular cells, so-called lymphoepithelial lesions are seen (H-E, ×200)

  • Fig. 4 Atypical lymphoid cells are positive for CD20 (IHC, ×200)

  • Fig. 5 Sections from thyroid gland showing typical histologic features of papillary carcinoma (H-E, ×100)


Cited by  1 articles

Autoimmune Thyroid Diseases
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Hanyang Med Rev. 2012;32(4):219-226.    doi: 10.7599/hmr.2012.32.4.219.


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