J Korean Orthop Res Soc.  2005 Apr;8(1):10-19.

The Effect of Low Level Laser on the Fracture Healing in Guinea Pig Femur

Affiliations
  • 1Department of Orthopaedic Surgery, Dankook University College of Medicine. heegon@chol.net
  • 2Department of Otolaryngology-Head and Neck Surgery, Dankook Univerisity College of Medicine.
  • 3Department fo anatomy, Seoul national university college fo Medicine.

Abstract

PURPOSE
This study was conducted to evaluate the effectiveness of the low level laser on the fracture-healing of the guinea pig femurs.
MATERIALS AND METHODS
This study was performed on 36 guinea pigs(17 in the experimental group and 19 in the control group). After anesthesia of the guinea pigs, the shaft of femur was fractured with Gigli saw under aseptic conditions, and then the intramedullary nailing of K-wire was performed. The application of low level laser on the fracture sites in the experimental group began 2 days after the operation under anesthesia, for 30 minutes every 2 days. The laser we used was a CW-type microchip laser with output wave length of 890 nm and intensity of 13 mWatts, measuring upto 4.68 J/cm2 per each application. In order to compare the femur fracture healing process of both groups; gross findings, simple radiologic findings, and histologic findings of fracture site stability were evaluated. The simple radiologic and histologic findings were assessed by the scoring system invented by Zorlu and his colleagues. The statistical evaluation was done by using repeative measured ANOVA test.
RESULTS
In both experimental and control groups, the gross findings progressed favorably. Although the improvement in radiologic findings were found in both groups with the passage of time, the experimental group showed a greater rate of callus formation with statistical significance(p<0.0) compared to the control group. The result of histological findings showed that a increase of osteoblastic proliferation was also greater in the experimental group(p<0.01).
CONCLUSION
In this study, the low level laser was revealed to be effective on acceleration of femur fracture healing in guinea pigs.

Keyword

Guinea Pig; Fracture healing; Low level laser

MeSH Terms

Acceleration
Anesthesia
Animals
Bony Callus
Femur*
Fracture Fixation, Intramedullary
Fracture Healing*
Guinea Pigs*
Guinea*
Osteoblasts
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