J Lipid Atheroscler.  2012 Dec;1(2):61-68. 10.12997/jla.2012.1.2.61.

The Associations between Alcohol Intake and HDL Cholesterol Subclasses in Korean Population

• Lim JE
• Kim JI
• Lee SJ
• Sull JW
• Lee M
• Jee SH

• KMID: 2198363
• DOI: http://doi.org/10.12997/jla.2012.1.2.61

Abstract

OBJECTIVE
Alcohol intake has been found to be associated with high-density lipoprotein (HDL) cholesterol. However, the association of alcohol intake with HDL cholesterol subclasses is unclear. Therefore, this study was conducted to determine the association between alcohol intake and HDL cholesterol subclasses among Koreans.
METHODS
This study included in 1,101 healthy Koreans (men: 765, women: 336) who underwent health check-up at two hospitals in the Korean Cancer Prevention Study 2 (KCPS2). The amounts of alcohol intake were classified into 4 groups: non-, light, moderate, and heavy drinkers (0, <12.5, 12.5-49.9, and > or =50.0 g/day, respectively). The proportions of HDL cholesterol subclasses were measured after subclasses were identified by 4-30% gradient gel electrophoresis. Multiple regression models were used to estimate regression coefficients after multivariate adjustments.
RESULTS
The concentration of HDL, HDL2 and HDL3 significantly increased with increasing amount of alcohol intake. After adjusted for age, body mass index (BMI), waist and smoking status, alcohol consumers of <12.5 g/day, 12.5-49.9 g/day and more than 50.0g/day showed significant positive associations with HDL, HDL2 and HDL3 concentration when compared to non-alcohol drinkers in men. In particular, The strongest positive associations were obtained with HDL2b and HDL3c.
CONCLUSION
HDL2 and HDL3 were significantly associated with increasing amount of alcohol intake in Koreans. In particular, HDL2b among HDL2 and HDL3c among HDL3 showed the strongest positive association with increasing amount of alcohol intake.

Keyword

HDL; HDL2; HDL3; Alcohol drinking

MeSH Terms

Alcohol Drinking
Body Mass Index
Cholesterol
Cholesterol, HDL
Electrophoresis
Humans
Light
Lipoproteins
Male
Smoke
Smoking
Cholesterol
Cholesterol, HDL
Lipoproteins
Smoke

Figure

• 

  Fig. 1 HDL2b (mg/dL) differences according to age, BMI, waist and smoking status. All figures are adjusted for sex, age, BMI, waist and smoking status except relevant variable.

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