J Korean Neuropsychiatr Assoc.
2005 Mar;44(2):221-231.
Gender Differences in Alcohol Metabolizing Hepatic Enzyme Genotypes in Korean Patients with Alcohol Dependence
- Affiliations
-
- 1Department of Psychiatry, Pusan National University, Busan, Korea. sungkim@pusan.ac.kr
- 2Department of Biochemistry, Pusan National University, Busan, Korea.
- 3Yang San Hospital, Yang San, Korea.
- 4Dasarang Hospital, Kwang Ju, Korea.
- 5Lee's Psychiatric Clinic, Busan, Korea.
- 6Division of Management Information Science, Dong-A University, Busan, Korea.
- 7Medical Research Institute, Pusan National University Hospital, Busan, Korea.
- 8Hyosim Hospital, Daegu, Korea.
- 9Department of Psychiatry, Dong-A University, Busan, Korea.
Abstract
OBJECTIVES
There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control.
METHODS
The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping.
RESULTS
First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects.
CONCLUSION
These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 genotype in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.
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