J Korean Neurol Assoc.  2009 Nov;27(4):405-408.

Thrombolytic Therapy of Pulmonary Thromboembolism in Probable Sporadic Creutzfeldt-Jakob Disease

Affiliations
  • 1Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.
  • 2Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

The effect of intravenous recombinant tissue plasminogen activator for patients with Creutzfeldt-Jakob disease (CJD) has yet to be determined. A woman with rapidly progressive cognitive decline, cerebellar dysfunction, and extrapyramidal symptoms, diagnosed as probable sporadic CJD, was complicated with pulmonary thromboembolism and systemic hypotension. Her vital signs were restored without brain parenchymal hemorrhage after intravenous thrombolysis. The presence of diffuse brain lesions in CJD did not increase the hemorrhagic complications associated with intravenous thrombolysis, which differs from an ischemic vascular event.

Keyword

Sporadic CJD; Pulmonary thromboembolism; Intravenous thrombolysis

MeSH Terms

Brain
Cerebellar Diseases
Creutzfeldt-Jakob Syndrome
Encephalopathy, Bovine Spongiform
Female
Hemorrhage
Humans
Hypotension
Pulmonary Embolism
Thrombolytic Therapy
Tissue Plasminogen Activator
Vital Signs
Creutzfeldt-Jakob Syndrome
Encephalopathy, Bovine Spongiform
Tissue Plasminogen Activator
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