J Korean Neurosurg Soc.  2015 Jun;57(6):396-400. 10.3340/jkns.2015.57.6.396.

Pediatric Stroke

• Jeong G
• Lim BC
• Chae JH

• KMID: 2191244
• DOI: http://doi.org/10.3340/jkns.2015.57.6.396

Abstract

Pediatric stroke is relatively rare but may lead to significant morbidity and mortality. Along with the advance of brain imaging technology and clinical awareness, diagnosis of pediatric stroke is increasing wordwide. Pediatric stroke differs from adults in variable risk factor/etiologies, diverse and nonspecific clinical presentation depending on ages. This review will be discussed pediatric stroke focusing on their clinical presentations, diagnosis and etiologies/risk factors.

Keyword

Pediatric; Stroke; Clinical; Risk factors; Etiology; Diagnosis

MeSH Terms

Adult
Diagnosis
Humans
Mortality
Neuroimaging
Risk Factors
Stroke*

Reference

1. Bowers KJ, Deveber GA, Ferriero DM, Roach ES, Vexler ZS, Maria BL. Cerebrovascular disease in children : recent advances in diagnosis and management. J Child Neurol. 2011; 26:1074–1100. PMID: 21778188.

2. Cárdenas JF, Rho JM, Kirton A. Pediatric stroke. Childs Nerv Syst. 2011; 27:1375–1390. PMID: 21336993.

3. deVeber G, Roach ES, Riela AR, Wiznitzer M. Stroke in children : recognition, treatment, and future directions. Semin Pediatr Neurol. 2000; 7:309–317. PMID: 11205720.

4. Earley CJ, Kittner SJ, Feeser BR, Gardner J, Epstein A, Wozniak MA, et al. Stroke in children and sickle-cell disease : Baltimore-Washington Cooperative Young Stroke Study. Neurology. 1998; 51:169–176. PMID: 9674798.

5. Freundlich CL, Cervantes-Arslanian AM, Dorfman DH. Pediatric stroke. Emerg Med Clin North Am. 2012; 30:805–828. PMID: 22974650.

6. Fullerton HJ, Wu YW, Sidney S, Johnston SC. Risk of recurrent childhood arterial ischemic stroke in a population-based cohort : the importance of cerebrovascular imaging. Pediatrics. 2007; 119:495–501. PMID: 17332202.

7. Ganesan V, Prengler M, McShane MA, Wade AM, Kirkham FJ. Investigation of risk factors in children with arterial ischemic stroke. Ann Neurol. 2003; 53:167–173. PMID: 12557282.

8. Kissela BM, Khoury JC, Alwell K, Moomaw CJ, Woo D, Adeoye O, et al. Age at stroke : temporal trends in stroke incidence in a large, biracial population. Neurology. 2012; 79:1781–1787. PMID: 23054237.

9. Lee EH, Yum MS, Ko TS. Risk factors and clinical outcomes of childhood ischemic stroke in a single Korean tertiary care center. J Child Neurol. 2012; 27:485–491. PMID: 21960673.

10. Lynch JK, Hirtz DG, DeVeber G, Nelson KB. Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics. 2002; 109:116–123. PMID: 11773550.

11. Mackay MT, Wiznitzer M, Benedict SL, Lee KJ, Deveber GA, Ganesan V. International Pediatric Stroke Study Group. Arterial ischemic stroke risk factors : the International Pediatric Stroke Study. Ann Neurol. 2011; 69:130–140. PMID: 21280083.

12. Meyer-Heim AD, Boltshauser E. Spontaneous intracranial haemorrhage in children : aetiology, presentation and outcome. Brain Dev. 2003; 25:416–421. PMID: 12907276.

13. Moharir M, Deveber G. Pediatric arterial ischemic stroke. Continuum (Minneap Minn). 2014; 20(2 Cerebrovascular Disease):370–386. PMID: 24699487.

14. Nelson KB, Lynch JK. Stroke in newborn infants. Lancet Neurol. 2004; 3:150–158. PMID: 14980530.

15. Per H, Unal E, Poyrazoglu HG, Ozdemir MA, Donmez H, Gumus H, et al. Childhood stroke : results of 130 children from a reference center in Central Anatolia, Turkey. Pediatr Neurol. 2014; 50:595–600. PMID: 24842257.

16. Rafay MF, Pontigon AM, Chiang J, Adams M, Jarvis DA, Silver F, et al. Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke. 2009; 40:58–64. PMID: 18802206.

17. Salih MA, Abdel-Gader AG, Al-Jarallah AA, Kentab AY, Gadelrab MO, Alorainy IA, et al. Infectious and inflammatory disorders of the circulatory system as risk factors for stroke in Saudi children. Saudi Med J. 2006; 27 Suppl 1:S41–S52. PMID: 16532131.

18. Salih MA, Al-Jarallah AS, Abdel-Gader AG, Al-Jarallah AA, Al-Saadi MM, Kentab AY, et al. Cardiac diseases as a risk factor for stroke in Saudi children. Saudi Med J. 2006; 27 Suppl 1:S61–S68. PMID: 16532133.

19. Salih MA, Murshid WR, Zahraa JN, Abdel-Gader AG, Al-Jarallah AA, Kentab AY, et al. Congenital and genetic cerebrovascular anomalies as risk factors for stroke in Saudi children. Saudi Med J. 2006; 27 Suppl:S53–S60. PMID: 16532132.

20. Shi KL, Wang JJ, Li JW, Jiang LQ, Mix E, Fang F, et al. Arterial ischemic stroke : experience in Chinese children. Pediatr Neurol. 2008; 38:186–190. PMID: 18279753.

21. Testai FD, Gorelick PB. Inherited metabolic disorders and stroke part 1 : Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Arch Neurol. 2010; 67:19–24. PMID: 20065125.

22. Testai FD, Gorelick PB. Inherited metabolic disorders and stroke part 2 : homocystinuria, organic acidurias, and urea cycle disorders. Arch Neurol. 2010; 67:148–153. PMID: 20142522.

23. Tsze DS, Valente JH. Pediatric stroke : a review. Emerg Med Int. 2011; 2011:734506. PMID: 22254140.

24. Younkin DP. Diagnosis and treatment of ischemic pediatric stroke. Curr Neurol Neurosci Rep. 2002; 2:18–24. PMID: 11898578.