J Korean Assoc Oral Maxillofac Surg.  2008 Aug;34(4):450-455.

Understanding of single nucleotide polymorphism of human genome

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung-Hee University, Korea. omsojh@khu.ac.kr

Abstract

A Single Nucleotide Polymorphism (SNP) is a small genetic change or variation that can occur within a DNA sequence. It's the difference of one base at specific base pair position. SNP variation occurs when a single nucleotide, such as an A, replaces one of the other three nucleotide letters-C, G, or T. On average, SNP occur in the human population more than 1 percent of the time. They occur once in every 300 nucleotides on average, which means there are roughly 10 million SNPs in the human genome. Because SNPs occur frequently throughout the genome and tend to be relatively stable genetically, they serve as excellent biological markers. They can help scientists locate genes that are associated with disease such as heart disease, cancer, diabetes. They can also be used to track the inheritance of disease genes within families. SNPs may also be associated with absorbance and clearance of therapeutic agents. In the future, the most appropriate drug for an individual could be determined in advance of treatment by analyzing a patient's SNP profile. This pharmacogenetic strategy heralds an era in which the choice of drugs for a particular patient will be based on evidence rather than trial and error (so called" personalized medicine").

Keyword

Single Nucleotide Polymorphism (SNP); Biological Marker; Personalized Medicine

MeSH Terms

Base Pairing
Base Sequence
Biomarkers
Genome
Genome, Human
Heart Diseases
Humans
Precision Medicine
Nucleotides
Polymorphism, Single Nucleotide
Track and Field
Wills
Nucleotides
Full Text Links
  • JKAOMS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error