J Korean Geriatr Soc.  2013 Dec;17(4):178-184. 10.4235/jkgs.2013.17.4.178.

Effectiveness Analysis Through Enzyme-Linked Immunosorbent Assay Examination of Antibody After Pandemic H1N1 2009 Influenza Vaccination

• Ji AY
• Kim CO
• Hwang E
• Kim IS
• Kim YJ
• Lee JH
• Jin MN
• Song C
• Park HJ
• Kim HJ
• Kim SW

• KMID: 2188221
• DOI: http://doi.org/10.4235/jkgs.2013.17.4.178

Abstract

BACKGROUND
A pandemic influenza outbreak started in 2009 by the number of patients discharged each year. But the result of H1N1 influenza vaccination is maintained for research and less state. The purpose of this study was to measure the antibody titers after H1N1 influenza vaccination toestimate demands of different standard vaccination in patients with chronic diseases and elderly patients.
METHODS
From March 2010 to February 2011, we retrospectively reviewed the medical records of 55 patients admitted to a tertiary hospital. The H1N1 virus antibody titer of each patient was measured through enzyme-linked immunosorbent assay. Titers were measured post vaccination on day 1 and at 1, 3 and 6 months.
RESULTS
A total of 55 patients were enrolled in this study. The comorbidities looked at were malignancy, cardiovascular disease, diabetes mellitus, renal disease, cerebrovascular disease, hematologic disease and infectious disease. Five patients (9.1%) had no comorbidities. Patients in their 50's had the highest positive response rate (58.3%). The antibody titers at 1 month after vaccination were not associated with the number of comorbidities. The ratio of positive response increased gradually at baseline (16.4%) to 1 month (47.8%). After 6 months, there remained no positive response.
CONCLUSION
The H1N1 antibodies were unstable as the values of the titer changed at follow-up (1 month, 3 months, and 6 months). The positive response rates of those in their 50's and those who had chronic diseases were higher than others. The positive response rates showed that the ability to generate antibodies did not decrease with age or disease conditions.

Keyword

H1N1 influenza; Comorbidity; H1N1 virus hemagglutinin; Vaccination

MeSH Terms

Aged
Antibodies
Cardiovascular Diseases
Chronic Disease
Communicable Diseases
Comorbidity
Diabetes Mellitus
Enzyme-Linked Immunosorbent Assay*
Follow-Up Studies
Hematologic Diseases
Humans
Influenza A Virus, H1N1 Subtype
Influenza, Human*
Medical Records
Pandemics*
Retrospective Studies
Tertiary Care Centers
Vaccination*
Antibodies