J Korean Med Assoc.  2009 Oct;52(10):952-962. 10.5124/jkma.2009.52.10.952.

Korean Hereditary Breast Cancer

• Kim SW

• KMID: 2188077
• DOI: http://doi.org/10.5124/jkma.2009.52.10.952

Abstract

Approximately 7% of all breast cancer cases are associated with hereditary predisposition and BRCA1 and BRCA2 gene, which accounts for half of the hereditary breast cancer (HBC). Although majority of breast cancer occur sporadically, identification of HBC is important in that active adoption of preventive strategies such as surveillance, chemoprevention, and riskreducing surgery will result in the gain of life-expectancy. According to the recent studies, the prevalence and penetrance of BRCA mutation in Korean breast cancer patients are comparable to that of western countries. Genetic testing should be done in the setting of genetic counseling, which provides the patients with comprehensive information about the test procedure, the interpretation of the test result, and possible options when the test results were positive for mutation. The management of HBC is not different from that of sporadic cancer and many clinical trials investigating the chemoprevention and targeted therapy of HBC are underway. The Korean Hereditary Breast Cancer (KOHBRA) study is a nationwide multicenter study to reveal the prevalence of BRCA mutation in Korean breast cancer patients. After the completion of the KOHBRA study, we expect important basic data which will be the backbone of clinical practice guideline for Korean HBC patients.

Keyword

Hereditary breast cancer; BRCA1; BRCA2; KOHBRA study

MeSH Terms

Adoption
Breast
Breast Neoplasms
Chemoprevention
Genes, BRCA2
Genetic Counseling
Genetic Testing
Humans
Penetrance
Prevalence

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