J Korean Neurosurg Soc.  1993 Feb;22(2):252-260.

Clinical Analysis of Stereotactic Brachytherapy with High-Activity Iridium-192 Sources for Treatment of Malignant Astrocytomas

Affiliations
  • 1Department of Neurosurgery, School of Medicine, Keimyung University, Taegu, Korea.
  • 2Department of Therapeutic Radiology, School of Medicine, Keimyung University, Taegu, Korea.

Abstract

Interstitial irradiation using high-activity Iridium-192 sources was studied clinically to treat supratentorial malignant astrocytomas(including glioblastoma multifrome). As of 1988, in attempt to define the efficacy of this technique in patients with more extensive disease, we treated patients less rigid selection criteria. 15 eligible patients have been approached and ten have accepted randomization for follow-up study over two years. Pathology was anaplastic astrocytoma in 5 patients, glioblastoma multiforme in 5 patients. Mean survival of patients treated with this procedure was 18.4 months. Continued investigation will determine which patient may benefit from this techique.

Keyword

Interstitial brachytheraphy; High-activity iridium-192; Malignant astrocytoma

MeSH Terms

Astrocytoma*
Brachytherapy*
Follow-Up Studies
Glioblastoma
Humans
Pathology
Patient Selection
Random Allocation
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