J Korean Orthop Assoc.  2007 Aug;42(4):490-497. 10.4055/jkoa.2007.42.4.490.

The Expression of the Adhesion Molecules on Interfacial Membrane fromthe Aseptically Loosened Failed Femoral Stems in Revisional Hip Arthroplasty

• Lee SH
• Hwang JH
• Kim DW
• Kim BK
• Jeong HW

• KMID: 2186511
• DOI: http://doi.org/10.4055/jkoa.2007.42.4.490

Abstract

PURPOSE: To clarify the relationship between aseptic loosening of hip arthroplasty and adhesion molecules on interfacial membrane from revisional hip arthroplasty.
MATERIALS AND METHODS
We studied 26 revisional total hip arthroplasties between May 2004 and July 2006, and 15 synovial tissues from hip fractures were selected as the control group. We analyzed the degree of femoral osteolysis by Paprosky's classification. We examined the expression of soluble endothelial leukocyte adhesion molecule-1 (E-selectin), vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) by immunohistochemical staining technique. We compared and analyzed radiologic evaluation and expression of adhesion molecules.
RESULTS
Expression of E-selectin was observed in 100%, VCAM-1 in 42.3% and ICAM-1 in 34.6%. Expression of adhesion molecules were increased compared to the control group (p<0.05). The higher the expression of E-selectin, the higher the degree of osteolysis (p=0.023).
CONCLUSION
These results showed that adhesion molecules are involved in aseptic loosening of hip arthroplasties, and we proposed that E-selectin may strongly engage in the cascade of aseptic loosening in hip arthroplasty.

Keyword

Interfacial membrane; Adhesion molecule; Aseptic loosening; Revisional hip arthroplasty

MeSH Terms

Arthroplasty*
Classification
E-Selectin
Hip Fractures
Hip*
Intercellular Adhesion Molecule-1
Membranes*
Osteolysis
Vascular Cell Adhesion Molecule-1
E-Selectin
Intercellular Adhesion Molecule-1
Vascular Cell Adhesion Molecule-1

Figure

• 

  Fig. 1 A microscopic image demonstrating vessels stained with antibody to E-selectin (arrow). (A) Negative for staining. (B) 1st grade of intensity and 1st grade of proportion. (C) 1st grade of intensity and 2nd grade of proportion (×100).

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