J Korean Neurol Assoc.  2010 Aug;28(3):203-205.

Isaacs' Syndrome Associated With Acetylcholine Receptor Antibodies Developed After Removal of Malignant Thymoma

Affiliations
  • 1Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea. ohsun@jbnu.ac.kr

Abstract

Isaacs' syndrome is a rare and heterogeneous syndrome of continuous muscle fiber activity that originates from peripheral nerves. We report a 56-year-old male patient who showed symptoms of Isaacs' syndrome after the removal of a malignant thymoma. Needle electromyography revealed spontaneously occurring repetitive myokymic discharge in the affected muscles. Acetylcholine receptor (AChR) antibodies were significantly elevated, but clinical and electrophysiologic findings did not indicate the presence of myasthenia gravis. We deduce that in Isaacs' syndrome, raised AChR antibodies may facilitate rather than inhibit cholinergic action.

Keyword

Isaacs's syndrome; Acetylcholine receptor antibody

MeSH Terms

Acetylcholine
Antibodies
Electromyography
Humans
Isaacs Syndrome
Male
Middle Aged
Muscles
Myasthenia Gravis
Needles
Peripheral Nerves
Thymoma
Acetylcholine
Antibodies
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