J Korean Neurol Assoc.  2015 Aug;33(3):173-177. 10.17340/jkna.2015.3.6.

The Usefulness of Cardiac Biomarker in Patients with Acute Ischemic Stroke

• Park SK
• Hwang S
• Lee SH
• Park SC
• Park S
• Han S
• Min MK
• Kim YI
• Ryu JH
• Yeom SR
• Park MR

• KMID: 2184593
• DOI: http://doi.org/10.17340/jkna.2015.3.6

Abstract

BACKGROUND
Cardiac enzymes such as creatine kinase-MB, troponin I, and brain natriuretic peptide (BNP) are thought to be useful prognostic factors in patients with acute ischemic stroke. This study investigated the efficacy of cardiac biomarkers as prognostic factors.
METHODS
We reviewed patients with acute ischemic stroke whose cardiac biomarkers had been measured and who were admitted to our hospital between January 2012 and December 2013. The cardiac biomarkers were measured within 24 hours after admission to the emergency room. We evaluated the clinical characteristics and compared the outcomes of the patients based on their cardiac biomarkers.
RESULTS
The following cardiac biomarkers were measured in 219 patients with acute ischemic stroke: creatine kinase-MB (n=218), troponin I (n=219), and BNP (n=143). Statistically significant differences were observed in older age (68.77+/-12.42 vs. 74.59+/-6.68, p<0.05), insula involvement (30.5% vs. 59.1%, p<0.01), and higher BNP (259.75+/-422.65 vs. 667.06+/-1093.22, p<0.01).
CONCLUSIONS
These results suggest that measuring all cardiac biomarkers may be not effective in determining the prognosis of acute ischemic stroke. However, BNP may be a superior to troponin I in predicting the prognosis.

Keyword

Cerebral infarction; Clinical markers; Prognosis

MeSH Terms

Biomarkers
Cerebral Infarction
Creatine
Emergency Service, Hospital
Humans
Natriuretic Peptide, Brain
Prognosis
Stroke*
Troponin I
Creatine
Natriuretic Peptide, Brain
Troponin I