J Asthma Allergy Clin Immunol.  2003 Dec;23(4):837-841.

A case of mycoplasma pneumonia associated with pulmonary and bronchial eosinophilia

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea. skleeai@daunet.donga.ac.kr
  • 2Department of Anatomic Pathology, College of Medicine, Dong-A University, Busan, Korea.
  • 3Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dong-A University, Busan, Korea.
  • 4Department of Diagnostic Radiology, College of Medicine, Dong-A University, Busan, Korea.

Abstract

Epidemiologic evidences suggest a close linking exist between Mycoplasma infection and asthma exacerbation, and possibly as a factor in the pathogenesis of asthma. However, little is known about the pathogenetic mechanism of respiratory M. pneumonia infection on airway inflammation. We report a case of mycoplasma pneumonia associated with pulmonary and bronchial eosinophilia. A 25-year-old man developed fever, coughing and dyspnea for 5 days prior to the admission. Initial chest x-ray showed bilateral interstitial or nodular infiltration and right pleural effusion. In High-resolution chest CT, demonstrated bilateral interstitial thickening with perivascular blurring. Pulmonary function test showed mild restrictive ventilatory pattern. Differential cell count in induced sputum showed marked eosinophilia(70% of non-squamous cells). Furthermore, bronchoalveolar lavage fluid analysis showed excessive eosinophils(39%). Mycoplasmal antibody was detected in patient's serum in titer of 1 to 160 by indirect hemagglutination method. Methacholine PC20 was 11.4 mg/ml. After treatment with macrolide antibiotics only, patient's subjective symptoms, abnormalities in chest x-ray film and bronchial hyperreactivity were disappeared.

Keyword

Mycoplasma; Eosinophilia; Bronchial Hyperreactivity

MeSH Terms

Adult
Anti-Bacterial Agents
Asthma
Bronchial Hyperreactivity
Bronchoalveolar Lavage Fluid
Cell Count
Cough
Dyspnea
Eosinophilia*
Fever
Hemagglutination
Humans
Inflammation
Methacholine Chloride
Mycoplasma Infections
Mycoplasma*
Pleural Effusion
Pneumonia
Pneumonia, Mycoplasma*
Respiratory Function Tests
Sputum
Thorax
Tomography, X-Ray Computed
X-Ray Film
Anti-Bacterial Agents
Methacholine Chloride
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