J Korean Endocr Soc.  2009 Sep;24(3):151-155. 10.3803/jkes.2009.24.3.151.

Is Triglyceride Atherogenic?

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea.

Abstract

No abstract available.


Figure

  • Fig. 1 The role of adipose tissue in triglyceride metabolism.

  • Fig. 2 The role of hepatocytes in triglyceride synthesis[1].

  • Fig. 3 The change of lipid metabolism under condition of insulin resistance (IR).

  • Fig. 4 The possible mechanism of triglyceride-rich lipoprotein (TRL) particles to induce atherosclerosis[4].

  • Fig. 5 The distribution of apoB100 and apoB48-containing particles in the atherogenic arterial wall[5].

  • Fig. 6 Triglycerides and CHD risk[8].


Reference

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2. Hussain MM, Bakillah A. New approaches to target microsomal triglyceride transfer protein. Curr Opin Lipidol. 2008. 19:572–578.
3. Iqbal J, Hussain MM. Intestinal lipid absorption. Am J Physiol Endocrinol Metab. 2009. 296:E1183–E1194.
4. Proctor SD, Vine DF, Mamo JC. Arterial retention of apolipoprotein B(48)- and B(100)-containing lipoproteins in atherogenesis. Curr Opin Lipidol. 2002. 13:461–470.
5. Proctor SD, Mamo JC. Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol. 2003. 23:1595–1600.
6. Dominiczak MH. Hyperlipidaemia and cardiovascular disease: nonfasting triglycerides gain momentum--but nothing changes on the metabolic syndrome front. Curr Opin Lipidol. 2008. 19:326–327.
7. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007. 298:299–308.
8. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, Boekholdt SM, Khaw KT, Gudnason V. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007. 115:450–458.
9. Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA. 2007. 298:309–316.
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