J Gynecol Oncol.  2012 Jan;23(1):43-47. 10.3802/jgo.2012.23.1.43.

Characteristics of thyroid incidentalomas detected by pre-treatment [18F]FDG PET or PET/CT in patients with cervical cancer

• Lee WM
• Kim BJ
• Kim MH
• Choi SC
• Ryu SY
• Lim I
• Kim K

• KMID: 2177513
• DOI: http://doi.org/10.3802/jgo.2012.23.1.43

Abstract

OBJECTIVE
Considering the increased use of [18F]FDG PET or PET/CT, the clinical significance of thyroid incidentalomas is the subject of controversy. The aim of this study was to determine the incidence of malignancies associated with thyroid incidentalomas detected by pre-treatment PET or PET/CT in patients with cervical cancer.
METHODS
We retrospectively reviewed the medical records of patients with cervical cancer who had thyroid incidentalomas detected by pre-treatment PET or PET/CT and were treated at our institute between January 2001 and December 2009.
RESULTS
Of 327 patients who underwent pre-treatment PET or PET/CT, 33 patients had thyroid incidentalomas (10.1%) and 4 patients were diagnosed with thyroid malignancies by percutaneous needle aspiration (PCNA) or surgery. To put it concretely, of 33 patients with thyroid incidentaloma, 16 patients had a diffuse uptake and 17 patients had a focal uptake. Four of 17 patients with focal uptake were diagnosed with thyroid malignancies (23.5%). One patient with a focal uptake had an atypical cell based on PCNA, but did not undergo additional studies. The mean SUVmax of thyroid malignancies did not differ from that of benign thyroid diseases.
CONCLUSION
Thyroid incidentalomas are frequently detected by pre-treatment PET or PET/CT in patients with cervical cancer. Focal uptake on PET or PET/CT has a high risk of thyroid cancer.

Keyword

Cervical cancer; Fluorodeoxyglucose F18; Positron-emission tomography; Positron-emission tomography and computed tomography; Histological confirmation; Thyroid incidentalomas

MeSH Terms

Fluorodeoxyglucose F18
Humans
Incidence
Medical Records
Needles
Positron-Emission Tomography
Positron-Emission Tomography and Computed Tomography
Proliferating Cell Nuclear Antigen
Retrospective Studies
Thyroid Gland
Thyroid Neoplasms
Uterine Cervical Neoplasms
Fluorodeoxyglucose F18
Proliferating Cell Nuclear Antigen

Figure

• 

  Fig. 1 Flow chart of patient selection process. PET, [18F]FDG PET; USG, ultrasoundgraphy; PCNA, percutaneous needle aspiration; AUS, atypia of undetermined significance.

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