Investig Magn Reson Imaging.  2015 Mar;19(1):62-66. 10.13104/imri.2015.19.1.62.

Neuroimaging and Clinicopathologic Findings of Lymphoplasmacyte-rich Meningioma, Mimicking Malignancy: Case Report

• Lee MY
• Ahn K
• Lee YS
• Jeun SS

• KMID: 2175579
• DOI: http://doi.org/10.13104/imri.2015.19.1.62

Abstract

Lymphoplasmacyte-rich meningioma is a rare WHO Grade I subtype of meningioma. The lymphoplasmacyte-rich meningioma does not have typical imaging features of a meningioma so it can mimic intracranial inflammatory condition or brain neoplasm. We report the clinicopathologic features of lymphoplasmacyte-rich meningioma in a 35-year-old woman. She suffered from progressive headache, dizziness and tinnitus over two years. The tumor exhibited atypical neuroimaging features, including obvious peritumoral edema and irregular enhancing components. She underwent total resection and histologic examination revealed a meningioma with numerous plasma cells. Her symptoms have since resolved and there has been no evidence of tumor recurrence after one year of follow-up.

Keyword

Lymphoplasmacyte-rich meningioma; Brain neoplasm; Intracranial inflammatory condition

MeSH Terms

Adult
Brain Neoplasms
Dizziness
Edema
Female
Follow-Up Studies
Headache
Humans
Meningioma*
Neuroimaging*
Plasma Cells
Recurrence
Tinnitus

Figure

• 

  Fig. 1 Non-enhanced CT demonstrates a cystic tumor mass with an internal fluid-fluid level and extensive brain edema, resulting in mid-line shift.

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  Fig. 2 The lesion demonstrates cystic component with hemorrhagic fluid-fluid level and extensive edematous change on axial T2-weighted image (a) and axial T1-weighted image (b). Irregular thick enhancing wall is noted on contrast-enhanced T1-weighted axial image (c). The mass shows broad dural based attachment on contrast-enhanced T1-weighted sagittal image (d).

• 

  Fig. 3 Photomicrograph (H & E staining) with low magnification view (a) shows lobules with massive plasma cell infiltration. High magnification view (b) demonstrates numerous plasma cells with Russel bodies (arrow). The tumor cells shows a few nuclear pseudoinclusions (c)

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