J Breast Cancer.  2009 Dec;12(4):302-308. 10.4048/jbc.2009.12.4.302.

Risk Factors of Local Recurrence after Breast Conserving Therapy in Invasive Breast Cancer

Affiliations
  • 1Depatment of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ahnsh@amc.seoul.kr
  • 2Depatment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • 3Depatment of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Abstract

PURPOSE
Twenty-year follow-up results of two pioneering randomized controlled trials have demonstrated equal patient survival after mastectomy and breast conservation therapy. The use of breast conservation therapy has undoubtedly provided substantial progress towards a better quality of life for women with breast cancer. Outcomes of breast conservation therapy performed at Asan medical center were retrospectively reviewed and analyses were performed to determine significant risk factors of local recurrence. METHODS: A total of 578 women with stage I, stage II or stage III breast cancer were treated with conservative surgery and radiation therapy between January 1997 and December 2002. Outcomes of local recurrence and survival were recorded. RESULTS: During a median follow-up of 54.1 months, 21 patients (3.6%) developed local recurrence as first event and 10 patients (1.7%) developed regional recurrence and 19 patients (3.3%) developed systemic recurrence. Univariate analysis of the prognostic factors determined that age (p=0.005), nuclear grade (p=0.013), estrogen receptor negativity (p=0.008), lymphovascular invasion (p=0.009), progesterone receptor negativity (p=0.016) and lack of hormone therapy (p=0.005) were statistically significant factors associated only with locoregional recurrence. Results of multivariate analysis determined that lymphovascular invasion (p=0.045) strongly independent predictors for local recurrence. CONCLUSION: Age, nuclear grade, estrogen receptor negativity, lymphovascular invasion, progesterone receptor negativity and lack of hormone therapy were associated with local recurrence after Breast conserving surgery. The lymphovascular invasion was the strongest independent risk factors for local recurrence.

Keyword

Breast conserving surgery; Breast neoplasms; Local recurrence; Risk factor

MeSH Terms

Breast
Breast Neoplasms
Estrogens
Female
Follow-Up Studies
Humans
Mastectomy
Mastectomy, Segmental
Multivariate Analysis
Quality of Life
Receptors, Progesterone
Recurrence
Retrospective Studies
Risk Factors
Estrogens
Receptors, Progesterone

Figure

  • Figure 1 Disease free survival curve according to risk factor.


Cited by  1 articles

Analysis of factors related systemic recurrence after breast conserving surgery in stage I breast cancer
Yoon-Seok Kim, Dong-Won Ryu, Chung-Han Lee
Kosin Med J. 2018;33(3):289-296.    doi: 10.7180/kmj.2018.33.3.289.


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