J Breast Cancer.  2009 Dec;12(4):257-264. 10.4048/jbc.2009.12.4.257.

Validation of Radiation Volume by Analysis of Recurrence Pattern in Breast-conserving Treatment for Early Breast Cancer

Affiliations
  • 1Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, Korea. cosuh317@yuhs.ac
  • 2Department of Surgery, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, Korea.

Abstract

PURPOSE
To assess the appropriateness of radiotherapy volume for patients receiving breast-conserving treatment (BCT) through analysis of recurrence pattern and factors affecting recurrence. METHODS: From 1991 to 1996, 362 patients who received BCT were retrospectively evaluated. The radiation volume was the involved breast alone in the patients with less than 4 positive axillary lymph nodes (LNs), and breast and supraclavicular fossa in patients with 4 or more positive axillary LNs. The median follow-up period was 123 months (range, 3-169 months). RESULTS: Ten-year overall, disease-free, local recurrence-free, and regional recurrence-free survival rates were 86.2%, 82.2%, 95.9%, and 95.2%, respectively. Among 310 patients receiving radiotherapy on the breast alone, 15 (4.8%) had regional recurrence. In particular, patients with inner quadrant lesions had high regional recurrence rates (11/98, 11.2%) (p<0.001). CONCLUSION: These low local recurrence rates may reveal that the current radiotherapy technique was successful. However, in cases of inner quadrant lesions, there were a considerable number of regional recurrences, even in N0 cases. This may suggest a potential role for irradiation on regional LNs in this group.

Keyword

Breast conserving surgery; Radiotherapy; Recurrence

MeSH Terms

Breast
Breast Neoplasms
Follow-Up Studies
Humans
Lymph Nodes
Mastectomy, Segmental
Recurrence
Retrospective Studies
Survival Rate

Figure

  • Figure 1 Kaplan-Meier plots of overall, cause-specific, and disease-free survival. Ten-year survival rates were 86.2%, 87.3%, and 82.2%, respectively.

  • Figure 2 Overall survival rate according to stage.


Cited by  1 articles

Predictors of 4 or More Positive Axillary Nodes in Patients with Nodepositive T1-2 Breast Carcinoma: The Indications for Adjuvant Irradiation of the Level III Axilla and Supraclavicular Fossa
Jong Hoon Lee, Sung Hwan Kim, Young Jin Suh, Byoung Yong Shim
J Breast Cancer. 2010;13(2):167-173.    doi: 10.4048/jbc.2010.13.2.167.


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